High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 against M. tuberculosis antigen.
P. Ogongo, A. Tran, F. Marzan, D. Gingrich, M. Krone, F. Aweeka, C. S. Lindestam Arlehamn, J. N. Martin, S. Deeks, P. W. Hunt, J. D. Ernst
The paper identifies two subsets of Th17 cells in HIV-ART-treated individuals with latent TB, showing subset 1 is reduced while IL17-producing cells remain, and links tryptophan catabolism to Th17 cell frequencies.
bioRxiv · Jan 6, 2023 · PreprintImmunology