C. S. Lindestam Arlehamn

The paper identifies differentially recognized T cell epitopes in Mtb infection stages using a proteome-wide screen and Fluorospot assay, revealing epitopes specific to active TB and potential vaccine targets.

The paper identifies two subsets of Th17 cells in HIV-ART-treated individuals with latent TB, showing subset 1 is reduced while IL17-producing cells remain, and links tryptophan catabolism to Th17 cell frequencies.

This study compares Mtb-specific CD4 T cell profiles in pericardial fluid and blood from PCTB patients, finding distinct phenotypes in PCF with no difference in cytokine production.

The paper investigates immune responses in individuals with MAC lung disease, finding reduced T-cell responses and hyperinflammatory monocyte activity.

The paper identifies PD-specific gene signatures in peripheral memory T cells by analyzing RNA-seq data from PD patients and healthy controls.

This study shows that acute SIV co-infection rapidly depletes CD4 T cells from tuberculosis granulomas before systemic CD4 T cell loss or disease reactivation.

This study identifies CD4+CCR6+ T cells as key drivers of the BCG-induced transcriptional response, showing similar immune signatures across individuals.

This study develops a Mycobacterium tuberculosis-specific subunit vaccine, H107, which when co-administered with BCG enhances immune responses and provides better protection than either vaccine alone.

This study shows that 5-OP-RU treatment of M. tuberculosis-infected rhesus macaques leads to MAIT cell dysfunction rather than expansion, with upregulated PD-1 and loss of cytokine production.

The paper identifies molecular signatures and methods to distinguish cell-cell complexes from singlet cells in flow cytometry data, highlighting their impact on data interpretation.