A. Tran

Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection

The paper identifies Rare Variable Mtb Antigens (RVMA) that induce Th17 responses in human TB infection, suggesting their potential as vaccine antigens to enhance Th17 immunity.

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model

This study investigates MLKL's non-necroptotic roles in diet-induced obesity and liver disease using a HFHFrHC mouse model, finding dose-dependent effects on inflammation and metabolic parameters.

Sex chromosome evolution in beetles

This study reconstructs karyotype evolution in beetles, identifying ancestral linkage groups and showing independent addition of autosomes to sex chromosomes.

High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 against M. tuberculosis antigen.

The paper identifies two subsets of Th17 cells in HIV-ART-treated individuals with latent TB, showing subset 1 is reduced while IL17-producing cells remain, and links tryptophan catabolism to Th17 cell frequencies.

Integrated Immunopeptidomics and Proteomics Study Reveals Imbalanced Innate and Adaptive Immune Responses to SARS-Cov-2 Infection

This study integrates immunopeptidomics and proteomics to show SARS-CoV-2 disrupts antigen presentation and alters HLA protein dynamics in Calu-3 cells.

Metabolic shift toward ketosis in asocial cavefish increases social-like affinity.

This study shows that a ketogenic diet increases social affinity in asocial cavefish, suggesting a link between metabolic shifts and social behavior.

Intranasal Immunization with a Proteosome-Adjuvanted SARS-CoV2 Spike Protein-Based Vaccine is Immunogenic and Efficacious in Mice & Hamsters

This study evaluates an intranasal vaccine formulation containing a proteosome-adjuvanted SARS-CoV-2 Spike protein, showing immunogenicity and efficacy in mice and hamsters against multiple variants.

Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer

The paper identifies three subtypes of MMR deficient colorectal cancer based on genetic and immune landscape evolution, linking them to T-cell infiltrates and checkpoint-inhibitor resistance.

Arsenal of Nanobodies for Broad-Spectrum Countermeasures against Current and Future SARS-CoV-2 Variants of Concerns

This paper presents a diverse set of nanobodies targeting SARS-CoV-2 spike glycoprotein with broad neutralization activity against multiple variants and high in vivo efficacy.

Sculpting rupture-free nuclear shapes in fibrous environments

The paper investigates how nuclei adapt to fibrous environments by studying cytoskeleton-mediated force transmission and its effect on nuclear shape.

The FDA-approved drug apremilast suppresses alcohol intake: clinical and pre-clinical validation

This study shows that the FDA-approved drug apremilast reduces excessive alcohol drinking in both preclinical models and human studies.

An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits potent immunity after a single dose.

This paper evaluates an enveloped virus-like particle vaccine, VBI-2902a, which elicits strong immunity against SARS-CoV-2 after a single dose in mice and hamsters.

Balanced Input from the tRNA Prenyltransferase MiaA Controls the Stress Resistance and Virulence Potential of Extraintestinal Pathogenic Escherichia coli

This study shows that MiaA, but not MiaB, is critical for the fitness and virulence of ExPEC, and that stress can alter MiaA expression to affect translation and proteome composition.

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis

This study shows MAIT cells are activated and dysfunctional in sepsis, contributing to protective cytokine responses in experimental sepsis but reduced in clinical cases.

Rift Valley fever in northern Senegal : a modelling approach to analyse the processes underlying virus circulation recurrence

This paper models RVF circulation in northern Senegal, finding that nomadic herd movements are sufficient to explain endemic virus circulation, with higher viraemic rates in animals arriving during the second half of the rainy season.

The N-end Rule Pathway and Ubr1 enforce protein compartmentalization via N-terminally-encoded cellular location signals

This study identifies a novel role for the N-end rule pathway in enforcing protein compartmentalization by degrading mislocalized organellar proteins.