S. Deeks

The effect of circulating neutralizing antibodies on the replication of SARS-CoV-2 variants following post-vaccination infections.

This study examines how pre-existing neutralizing antibodies affect viral shedding in post-vaccination SARS-CoV-2 infections, finding that higher titers reduce viral load and duration but are less effective against Omicron variants.

High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 against M. tuberculosis antigen.

The paper identifies two subsets of Th17 cells in HIV-ART-treated individuals with latent TB, showing subset 1 is reduced while IL17-producing cells remain, and links tryptophan catabolism to Th17 cell frequencies.

HIV-specific CD8 T cells from elite controllers have an epigenetic imprint that preserves effector functions

This study identifies epigenetic and transcriptional features in HIV-specific CD8 T cells from elite controllers that support long-lived effector functions and developmental potential.

Global profiling of human blood ILC subtypes reveals that NK cells produce homeostatic cytokine amphiregulin and sheds light on HIV-1 pathogenesis

This study identifies NK cell production of amphiregulin in human blood ILCs and links it to HIV-1 pathogenesis through cytokine signaling and immune cell dynamics.

IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence

The paper shows IL-10 promotes HIV persistence by supporting memory T cell survival and Tfh differentiation, and inhibiting IL-10 reduces HIV reservoirs.

The CCL2 Chemokine Promotes Early Seeding of the Latent HIV Reservoir

This study shows that CCL2 chemokine promotes early HIV reservoir formation by recruiting CCR2/5+ CD4 T cells to sites of inflammation during acute infection.

Microbiome and Metabolome driven differentiation of TGF-beta producing Tregs leads to Senescence and HIV latency

The paper identifies cellular senescence and TGF-beta pathways in HIV-infected individuals that contribute to HIV latency and poor immune recovery, suggesting potential therapeutic targets.

FOXO1 promotes HIV Latency by suppressing ER stress in T cells

This study shows FOXO1 promotes HIV latency by suppressing ER stress in T cells and identifies pathways to selectively reverse quiescence and reduce viral reservoirs.

Chromatin Functional States Correlate with HIV Latency Reversal in Infected Primary CD4+ T Cells

The paper identifies that latency reversing agents reactivate less than 5% of latent HIV proviruses and shows distinct chromatin functional states between reactivated and non-reactivated cells.