Author

D. Graham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Blomme· 1 shared A. Di Re· 1 shared A. Giacalone· 1 shared A. J. Brooks· 1 shared A. L. Cunningham· 1 shared A. N. Harman· 1 shared A. Rushin· 1 shared B. Bullock· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperCancer Biology

A. Blomme

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Detecting altered hepatic lipid oxidation by MRI in an animal model of NAFLD

M. A. McLeod, M. Ragavan, M. Chang, R. Mahar, A. Giacalone, A. Rushin, M. Glanz, V. Malut, D. Graham, N. Sunny, M. Merritt

This study develops an MRI-based method to detect altered hepatic lipid oxidation in a NAFLD mouse model, showing decreased β-oxidation efficiency as a potential prognostic indicator.

bioRxiv · Aug 16, 2023 · PreprintBiochemistry

An Innovative Non-Hormonal Strategy Targeting Redox Active Metals to Down-Regulate Estrogen-, Progesterone-, Androgen- and Prolactin-Receptors in Breast Cancer

F. Shehadeh-Tout, H. H. Milioli, S. Roslan, P. J. Jansson, M. Dharmasivam, D. Graham, R. Anderson, T. Wijesinghe, M. G. Azad, D. R. Richardson, Z. Kovacevic

This paper investigates the effects of redox-active compounds Dp44mT and DpC on hormone receptors and resistance pathways in breast cancer, showing they suppress receptor expression and signaling through metal ion binding.

bioRxiv · Feb 2, 2023 · PreprintCancer Biology

THEM6-mediated lipid remodelling sustains stress resistance in cancer

A. Blomme, C. Peter, E. Mui, G. Rodriguez Blanco, L. M. Mason, L. E. Jamieson, G. H. McGregor, S. Lilla, C. Ntala, R. Patel, M. Thiry, S. H. Kung, C. A. Ford, L. K. Rushworth, D. J. McGarry, , H. Y. Leung

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

bioRxiv · Apr 4, 2021Cancer Biology

Identification of HIV-Transmitting Sub-Epithelial Mononuclear Phagocytes in Human Anogenital and Colorectal Tissues

J. W. Rhodes, R. A. Botting, K. M. Bertram, H. Rana, H. Baharlou, E. E. Longmuir-Vine, P. Vegh, J. Fletcher, T. R. O'Neil, G. P. Parnell, D. Graham, N. Nasr, J. J. K. Lim, L. Barnouti, P. Haertsch, , A. N. Harman

This study identifies two sub-epithelial mononuclear phagocyte subsets that preferentially uptake and transmit HIV to CD4 T cells in anogenital and colorectal tissues.

bioRxiv · May 26, 2020 · PreprintImmunology

Social Stress Alters Immune Response and Results in Higher Viral Load During Acute SIV Infection in a Pigtailed Macaque Model of HIV

S. M. Guerrero-Martin, L. H. Rubin, K. M. Mcgee, E. N. Shirk, S. E. Queen, M. Li, B. Bullock, B. W. Carlson, R. J. Adams, L. Gama, D. Graham, C. Zink, J. E. Clements, J. L. Mankowski, K. A. Metcalf Pate

This study shows that social stress in SIV-infected macaques increases viral load and T cell activation during acute infection compared to socially housed animals.

bioRxiv · Apr 21, 2020 · PreprintMicrobiology