S. Lilla

CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge

The helminth TGF-beta mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-beta receptors to preferentially target myeloid cells

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.

Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity

This study engineers extracellular vesicles from epithelial cells to express immunomodulatory proteins, showing they can induce both positive and negative T cell co-stimulation in cancer and autoimmunity.

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent NF-κB inflammatory response

This study shows that mitochondrial outer membrane permeabilization triggers ubiquitin-dependent NF-κB inflammation by recruiting NEMO to ubiquitylated mitochondria.

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

This study shows that mitochondrial DNA mutations in complex I genes drive aerobic glycolysis, enhancing immune checkpoint blockade response in tumors.

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

CAFs with a myofibroblastic-like phenotype transfer proteins to ECs, including plasma membrane receptors, through matrix-bound EVs.

PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.

This study identifies ARF6 as a critical vulnerability in PTEN-deficient ovarian cancer, showing its role in integrin-dependent invasion and its inverse association with patient outcomes.

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation

This study identifies palmitate-rich metastatic niches as promoters of metastasis by enhancing p65 acetylation and NF-κB signaling in breast cancer cells.

MICAL1 activation by PAK1 mediates actin filament disassembly

This study identifies PAK1-mediated phosphorylation of MICAL1 as a mechanism for actin filament disassembly, linking extracellular signals to cytoskeleton regulation through RHO GTPase signaling.

Maturation, developmental site, and pathology dictate murine neutrophil function

This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.

THEM6-mediated lipid remodelling sustains stress resistance in cancer

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis.

This study identifies IQSEC1 variants that spatially regulate phosphoinositide metabolism to switch cell behavior from growth to invasion, with implications for metastasis.

Schlafen family member 5 (SLFN5) regulates LAT1-mediated mTOR activation in castration-resistant prostate cancer

This study identifies SLFN5 as an AR-regulated biomarker in CRPC that promotes tumour growth by regulating LAT1-mediated mTOR activation.

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

The Mammalian Cytosolic Thioredoxin Reductase Pathway Acts via a Membrane Protein to Reduce ER-localised Proteins

The paper demonstrates that the cytosolic thioredoxin reductase pathway reduces ER-localized proteins via a membrane protein, essential for ER redox homeostasis and protein folding.

Formate induces a metabolic switch in nucleotide and energy metabolism

This study shows formate induces a metabolic switch increasing adenine nucleotides, glycolysis, and repressing AMPK, with implications for cancer metabolism.

Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation, which controls pseudopod lifetime

The paper shows that cell-substrate adhesion drives Scar/WAVE phosphorylation, which limits pseudopod lifetime, independent of chemotactic signals.

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

This study identifies CYRI proteins as local inhibitors of Scar/WAVE-induced lamellipodia that bind to active Rac1, regulating protrusion size and complexity.