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D. Heckmann

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Evolutionary Biology· 1

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Approach:statistical model· 1

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B. O. Palsson· 1 shared D. C. Zielinski· 1 shared

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B. O. Palsson

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Evolutionary BiologybioRxivMay 10, 2018

Modeling genome-wide evolution of catalytic turnover rates: Strong epistasis shaped modern enzyme kinetics

D. Heckmann, D. C. Zielinski, B. O. Palsson

The paper models the evolution of enzyme turnover rates using genome-scale metabolic and population genetics models, finding strong epistasis shapes kcat evolution and limits adaptation.

DOI 10.1038/s41467-018-07649-1

statistical model

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