BiochemistrybioRxiv
Human telomere repeat binding factor TRF1 replaces TRF2 bound to shelterin core hub TIN2 when TPP1 is absent
C. Hofr, T. Janovic, M. Stojaspal…·D. Horakova
The paper uses single-molecule techniques to show TRF1 can replace TRF2 on TIN2 when TPP1 is absent, and TPP1 enables simultaneous binding of both TRF1 and TRF2 to TIN2.
DOI 10.1016/j.jmb.2019.05.038