Author

D. Humes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Overbaugh· 3 shared H. L. Itell· 2 shared F. Roesch· 1 shared J. J. Delrow· 1 shared J. Vermeire· 1 shared L. Pendergast· 1 shared M. Emerman· 1 shared M. Ohainle· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

J. Overbaugh

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3 papers

Recent·Most cited

Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1

H. L. Itell, D. Humes, N. E. Baumgarten, J. Overbaugh

The paper identifies SLC35A2 as a host factor that influences HIV-1 tropism by modulating glycosylation, favoring R5 over X4 infection.

bioRxiv · Sep 5, 2023Microbiology

Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4+ T cells

H. L. Itell, D. Humes, J. Overbaugh

This study identifies multiple ISGs that restrict HIV-1 in primary CD4+ T cells through CRISPR-knockout screens and shows their combined protective effect against diverse HIV strains.

Cell Reports · Jun 1, 2023Peer-reviewedMicrobiology

A Virus-Packageable CRISPR Screen Identifies Host Factors Mediating Interferon Inhibition of HIV

M. Ohainle, L. Pendergast, J. Vermeire, F. Roesch, D. Humes, R. Basom, J. J. Delrow, J. Overbaugh, M. Emerman

The paper uses a CRISPR screen to identify host factors that mediate interferon inhibition of HIV replication, finding several restriction factors and novel dependencies.

bioRxiv · Jul 20, 2018Microbiology