Author

M. Ohainle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Organism:human· 6 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Approach:genetic perturbation / CRISPR· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:ChIP-seq· 1

Frequent Co-Authors

M. Emerman· 5 shared A. Felton· 3 shared F. Roesch· 2 shared A. Baidaliuk· 1 shared A. Hardy· 1 shared A. Khalifeh· 1 shared A. Mac Kain· 1 shared A. P. Fernandes· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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5 shared papersMicrobiology

M. Emerman

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Patterns of evolution of TRIM genes highlight the evolutionary plasticity of antiviral effectors in mammals

A. P. Fernandes, M. Ohainle, P. J. Esteves

The paper analyzes the evolution of TRIM genes across mammals, showing that their accumulation patterns vary among orders, reflecting immune system adaptation to retrovirus infections.

bioRxiv · May 3, 2023Evolutionary Biology

Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor

J. Twentyman, A. Khalifeh, A. Felton, M. Emerman, M. Ohainle

This study identifies primate TRIM34 as a lentiviral restriction factor that requires TRIM5 for activity, restricting multiple SIV capsids across primate species.

bioRxiv · Mar 24, 2023Immunology

A Virus-Packageable CRISPR System Identifies Host Dependency Factors Across Multiple HIV-1 Strains

V. R. Montoya, T. M. Ready, A. Felton, S. R. Fine, M. OhAinle, M. Emerman

The paper identifies host dependency factors for HIV replication across multiple strains using a virus-packageable CRISPR system in human T cells.

bioRxiv · Nov 3, 2022 · PreprintMicrobiology

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

E. Hsieh, D. H. Janssens, P. J. Paddison, E. P. Browne, S. Henikoff, M. Ohainle, M. Emerman

This study uses a CRISPR screen to identify pathways involved in HIV-1 latency, finding that ING3 and AZD5582 combination activates proviruses.

bioRxiv · Aug 23, 2022Microbiology

Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen

A. Mac Kain, G. Maarifi, S.-M. Aicher, N. Arhel, A. Baidaliuk, S. Munier, F. Donati, T. Vallet, Q. D. Tran, A. Hardy, M. Chazal, F. Porrot, M. Ohainle, J. Carlson-Stevermer, J. Oki, , F. Roesch

The paper identifies DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen, showing it limits viral replication independently of SUMOylation.

bioRxiv · May 6, 2021Microbiology

TRIM34 acts with TRIM5 to restrict HIV and SIV capsids

M. Ohainle, K. Kim, S. Keceli, A. Felton, E. M. Campbell, J. Luban, M. Emerman

This study identifies TRIM34 as an HIV-1 capsid-targeting restriction factor that acts with TRIM5alpha to restrict HIV and SIV infection during reverse transcription.

bioRxiv · Oct 30, 2019 · PreprintMicrobiology

A Virus-Packageable CRISPR Screen Identifies Host Factors Mediating Interferon Inhibition of HIV

M. Ohainle, L. Pendergast, J. Vermeire, F. Roesch, D. Humes, R. Basom, J. J. Delrow, J. Overbaugh, M. Emerman

The paper uses a CRISPR screen to identify host factors that mediate interferon inhibition of HIV replication, finding several restriction factors and novel dependencies.

bioRxiv · Jul 20, 2018Microbiology