Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy
P. Pandya, F. P. Vendetti, J. A. El-Ghoubaira, S. Pathak, J. J. Deppas, R. E. Jones, A. V. Columbus, Y. Zhang, D. Ivanov, Z. Huang, K. M. MacDonald, S. M. Harding, R. Buj, K. M. Aird, J. H. Beumer, , C. J. Bakkenist
The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.
bioRxiv · Apr 4, 2024 · PreprintCancer Biology