S. Pathak

A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in mice

This study maps the ontogeny of Treg subsets in mice, showing naive and effector/memory Treg are continuously replenished by de novo generation, with naive Treg being the main precursor of EM Treg in adults.

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells.

This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.

Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

PIM kinase control of CD8 T cell protein synthesis and cell trafficking

This study shows PIM kinases selectively regulate IL-2-driven protein synthesis and trafficking in CD8 T cells, without major effects on transcriptional programs.

Functional loss of rffG and rfbB, encoding dTDP-glucose 4,6-dehydratase, changes colony morphology, cell shape, motility and virulence in Salmonella Typhimurium

This study shows that deleting both rffG and rfbB in Salmonella Typhimurium causes changes in cell shape, motility, and virulence.

Fibroblast growth factor-21 induces skeletal muscle atrophy and increases plasma amino acids in female mice: a potential role for glucocorticoids

This study shows FGF21 induces skeletal muscle atrophy and increases plasma amino acids in female mice, likely via glucocorticoid signaling and HPA axis activation.

Unraveling the Potential Role of Tecomella undulata in Experimental NASH

This study investigates the effects of Tecomella undulata on NASH in mice, finding it reduces weight, insulin resistance, liver enzymes, and inflammation, comparable to Saroglitazar.

Increasing Muscle Hypertrophy with a Natural Product Designed to Inhibit SIRT1

This study tests natural product inhibitors of SIRT1 to enhance muscle hypertrophy, finding a 62% increase in fiber cross-sectional area with an optimal combination.

High Light and High Temperature Reduce Photosynthesis via Different Mechanisms in the C4 Model Setaria viridis

This study examines how high light and high temperature affect photosynthesis in Setaria viridis, revealing distinct mechanisms and acclimation strategies in C4 plants.

Chromosome size affects sequence divergence between species through the interplay of recombination and selection

The paper investigates how chromosome size influences sequence divergence between species by analyzing empirical data and evolutionary simulations across mammalian clades.

Constitutive overexpression of RAM1 increases arbuscule density during arbuscular mycorrhizal symbiosis in Brachypodium distachyon

This study shows that overexpressing RAM1 in Brachypodium distachyon increases arbuscule density during AM symbiosis but also causes growth defects.

How strategy environment and wealth shape altruistic behaviour: Cooperation rules affecting wealth distribution in dynamic networks

The paper introduces a decision heuristic that links cooperation and wealth distribution in dynamic networks, showing that final cooperation levels depend on strategy environment influence but not network restructuring.

Excessive ENaC-mediated sodium influx drives NLRP3 inflammasome-dependent autoinflammation in Cystic Fibrosis

This study shows that excessive ENaC-mediated sodium influx drives NLRP3 inflammasome-dependent autoinflammation in Cystic Fibrosis, with potential therapeutic implications for lung inflammation.