Author

D. J. Rolfe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

M. L. Martin-Fernandez· 2 shared A. C. Kalli· 1 shared A. Chu· 1 shared A. L. Duncan· 1 shared B. M. Davis· 1 shared C. J. Tynan· 1 shared D. T. Clarke· 1 shared E. Seiradake· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

M. L. Martin-Fernandez

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2 papers

Recent·Most cited

The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers

R. S. Iyer, S. R. Needham, I. Galdadas, B. M. Davis, S. K. Roberts, R. C. Man, L. C. Zanetti-Domingues, D. T. Clarke, G. O. Fruhwirth, P. J. Parker, D. J. Rolfe, F. L. Gervasio, M. L. Martin-Fernandez

This study identifies how the T766M-EGFR mutation promotes tumor growth by utilizing new oligomer assembly mechanisms in ligand-free EGFR.

bioRxiv · Jun 16, 2023 · PreprintCancer Biology

The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs

V. Jackson, J. Hermann, C. J. Tynan, D. J. Rolfe, R. A. Corey, A. L. Duncan, M. Noriega, A. Chu, A. C. Kalli, E. Y. Jones, M. Sansom, M. L. Martin-Fernandez, E. Seiradake, M. Chavent

This study identifies cis dimerization of FLRT2 via transmembrane and extracellular motifs, suggesting a competitive interaction mechanism with trans interactions.

bioRxiv · Oct 6, 2020Biophysics