A. Chu

The maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehavioral impairment in mice

This study shows that maternal microbiome alterations during protein undernutrition in mice modify offspring neurobehavioral impairments, with microbiome-targeted interventions offering potential mitigation.

Ezh2 as an epigenetic checkpoint regulator during monocyte differentiation: a potential target to improve cardiac repair after myocardial infarction

This study shows that inhibiting EZH2 improves cardiac repair after myocardial infarction by enhancing monocyte repair functions and reducing cardiac dysfunction.

A fear conditioned cue orchestrates a suite of behaviors

This study shows that a fear conditioned cue elicits a suite of behaviors including locomotion, jumping, rearing, and freezing, with sex-specific effects and distinct temporal profiles.

AFP2 inhibits ABA responses during germination without ABI5 degradation but DWAs reduce desiccation tolerance

This study shows AFP2 overexpression causes extreme ABA resistance without ABI5 degradation, and identifies desiccation tolerance mechanisms independent of ABA sensitivity.

Single-Cell Transcriptomic Analysis of Livers During NLRP3 Inflammasome Activation Reveals a Novel Immune Niche

This study uses single-cell transcriptomics to show NLRP3 activation in mice causes chronic extramedullary myelopoiesis and fibrosis in the liver.

The structural basis of fatty acid elongation by the ELOVL elongases

The paper reports the structure of the human ELOVL7 elongase, revealing its catalytic mechanism and substrate-binding sites, with implications for inhibiting VLCFA accumulation in diseases.

The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs

This study identifies cis dimerization of FLRT2 via transmembrane and extracellular motifs, suggesting a competitive interaction mechanism with trans interactions.

A new paradigm for Prelamin A proteolytic processing by ZMPSTE24: the upstream SY^LL cleavage occurs first and there is no CaaX processing by ZMPSTE24

This study challenges the established order of prelamin A processing by ZMPSTE24, showing that SY^LL cleavage occurs first and independently of C-terminal modifications.

Selective Plane Illumination Microscopy and Computing Reveal Differential Obliteration of Retinal Vascular Plexuses

The paper uses 3-D imaging and computational analysis to show preferential obliteration of retinal secondary plexuses in hyperoxia-induced retinopathy.

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

This study identifies TMEM16K as an ER-resident calcium-regulated lipid scramblase and elucidates its structural basis for lipid scrambling and inactivation.

Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design

This paper determines the structures of DPAGT1 with substrates and inhibitors, revealing catalytic mechanisms and disease-causing mutations, and designs non-toxic antibiotics for tuberculosis.