Author

M. Chavent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:mechanistic / dynamical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Schahl· 2 shared M. Sansom· 2 shared N. Destainville· 2 shared R. A. Corey· 2 shared A. C. Kalli· 1 shared A. Chu· 1 shared A. JEGOU· 1 shared A. L. Duncan· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

A. Schahl

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Histidine 73 methylation coordinates ????-actin plasticity in response to key environmental factors

A. Schahl, L. Lagardere, B. Walker, P. Ren, H. Wioland, M. Ballet, A. JEGOU, M. Chavent, J.-P. Piquemal

This study uses molecular dynamics simulations to show that H73 methylation in β-actin affects nucleotide binding, allosteric pathways, and phosphate release, regulating actin plasticity in response to environmental factors.

bioRxiv · Dec 16, 2022Biophysics

From Molecular Dynamics to Supramolecular Organization: The Role of PIM Lipids in the Originality of the Mycobacterial Plasma Membrane

C. M. Brown, R. A. Corey, Y. Gao, Y. K. Choi, M. Gilleron, N. Destainville, E. Fullam, W. Im, P. J. Stansfeld, M. Chavent

This paper uses molecular dynamics simulations to study the role of PIM lipids in the structure and organization of the Mycobacterial plasma membrane and validates findings with drug testing.

bioRxiv · Jun 29, 2022Biophysics

Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis

D. Zivkovic, A. Sanchez Dafun, T. Menneteau, A. Schahl, S. Lise, C. Kervarrec, A. Toste-Rego, P. da Fonseca, M. Chavent, C. Pineau, O. Schiltz, J. Marcoux, M.-P. Bousquet

This study maps proteasome composition and interactomes during spermatogenesis, revealing structural and functional changes in the spermatoproteasome (s20S) and its role in germ cell differentiation.

bioRxiv · Jun 18, 2021Biochemistry

The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs

V. Jackson, J. Hermann, C. J. Tynan, D. J. Rolfe, R. A. Corey, A. L. Duncan, M. Noriega, A. Chu, A. C. Kalli, E. Y. Jones, M. Sansom, M. L. Martin-Fernandez, E. Seiradake, M. Chavent

This study identifies cis dimerization of FLRT2 via transmembrane and extracellular motifs, suggesting a competitive interaction mechanism with trans interactions.

bioRxiv · Oct 6, 2020Biophysics

The conical shape of DIM lipids promotes Mycobacterium tuberculosis infection of macrophages

J. Augenstreich, E. Haanappel, G. Ferre, G. Czaplicki, F. Jolibois, N. Destainville, C. Guilhot, A. Milon, C. Astarie-Dequeker, M. Chavent

This study identifies the conical shape of DIM lipids as a key factor in promoting Mycobacterium tuberculosis infection of macrophages through phagocytosis.

bioRxiv · Jun 3, 2019Biophysics

Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and Class F G protein-coupled receptor Smoothened

G. Hedger, H. Koldsoe, M. Chavent, C. Siebold, R. Rohatgi, M. Sansom

The paper identifies cholesterol interaction sites on the transmembrane domain of the GPCR Smoothened using molecular dynamics simulations and free energy calculations.

bioRxiv · Aug 2, 2018Biophysics