Author

A. L. Duncan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:mechanistic / dynamical model· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

M. Sansom· 3 shared R. A. Corey· 3 shared P. J. Stansfeld· 2 shared W. Song· 2 shared A. B. Ward· 1 shared A. C. Kalli· 1 shared A. Chu· 1 shared A. J. Welch· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

M. Sansom

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer

A. Panda, F. Giska, A. L. Duncan, A. J. Welch, C. Brown, R. McAllister, H. Parameswaran, J. N. D. Goder, J. Coleman, S. Ramakrishnan, F. Pincet, L. Guan, S. Krishnakumar, J. E. Rothman, K. Gupta

This paper develops a platform for analyzing integral membrane proteins and lipids in intact membranes using native mass spectrometry, showing how lipid binding and membrane composition affect protein function.

bioRxiv · Mar 12, 2023Biophysics

Cardiolipin, and not monolysocardiolipin, preferentially binds to the interface of Complexes III and IV

R. A. Corey, N. Harrison, P. J. Stansfeld, M. S. P. Sansom, A. L. Duncan

This study shows that cardiolipin, not monolysocardiolipin, preferentially binds to the interface of mitochondrial supercomplexes containing Complexes III and IV, suggesting MLCL disrupts supercomplex stability in Barth syndrome.

bioRxiv · Jul 21, 2022Biochemistry

LipIDens: Simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins.

T. B. Ansell, W. Song, C. E. Coupland, L. Carrique, R. A. Corey, A. L. Duncan, C. K. Cassidy, M. M. G. Guerts, T. Rasmussen, A. B. Ward, C. Siebold, P. J. Stansfeld, M. Sansom

LipIDens uses MD simulations to interpret lipid-like densities in cryo-EM maps of membrane proteins, revealing protein-lipid interactions.

bioRxiv · Jun 30, 2022Biophysics

The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs

V. Jackson, J. Hermann, C. J. Tynan, D. J. Rolfe, R. A. Corey, A. L. Duncan, M. Noriega, A. Chu, A. C. Kalli, E. Y. Jones, M. Sansom, M. L. Martin-Fernandez, E. Seiradake, M. Chavent

This study identifies cis dimerization of FLRT2 via transmembrane and extracellular motifs, suggesting a competitive interaction mechanism with trans interactions.

bioRxiv · Oct 6, 2020Biophysics

Modulation of GPCR Oligomerisation by Conformational State and PIP2 Interactions Revealed by MD Simulations and Markov Models

W. Song, A. L. Duncan, M. Sansom

This study uses MD simulations and Markov models to show that A2aR activation increases oligomerisation diversity and connectivity, with PIP2 stabilizing protein interactions.

bioRxiv · Jun 24, 2020 · PreprintBiophysics