ImmunologybioRxiv
Selective B cell depletion upon intravenous infusion of replication-incompetent anti-CD19 CAR lentivirus
C. M. Rive, E. Yung, L. Dreolini…·R. A. Holt
This study shows that IV infusion of anti-CD19 CAR lentiviral vectors leads to persistent CAR-T cell expansion and complete B cell depletion in mice.
DOI 10.1016/j.omtm.2022.05.006