Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies
C.-Y. Lee, C. J. Caceres, G. Geiger, B. Seibert, F. C. Faccin, L. C. Gay, L. M. Ferreri, D. Kaul, J. Wrammert, G. S. Tan, D. R. Perez, A. C. Lowen
This study shows that influenza A virus escape from stem-binding antibodies incurs fitness costs, but epistatic interactions can mitigate these costs in some contexts.
bioRxiv · Jul 14, 2022 · PreprintMicrobiology