Author

G. Geiger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Organism:mouse· 4 Assay:metagenomics· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. R. Perez· 9 shared S. Carnaccini· 6 shared C. J. Caceres· 5 shared D. S. Rajao· 4 shared L. C. Gay· 4 shared L. M. Ferreri· 4 shared B. A. Seibert· 3 shared A. C. Lowen· 2 shared

Activity by Year

2021-2024 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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9 shared papersMicrobiology

D. R. Perez

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Differential Cross-Protective Immunity is Elicited by Infection with Contemporary Influenza B Lineage Viruses

C. Page, J. Y. Akinpelu, J. D. Shepard, G. Geiger, S. D. Ray, S. M. Tompkins

This study shows that contemporary Influenza B Victoria viruses provide cross-protection against Yamagata viruses, while Yamagata viruses do not offer similar protection, suggesting neuraminidase antibodies may be key to this asymmetry.

bioRxiv · Apr 15, 2024 · PreprintMicrobiology

FLUAV RAM-IGIP: A modified live influenza virus vaccine that enhances humoral and mucosal responses against influenza

C. J. Caceres, L. C. Gay, A. Jain, T. Mejias, M. Cardenas Perez, B. A. Seibert, F. Faccin, B. Cowan, G. Geiger, A. L. Vincent Baker, S. Carnaccini, D. H. Davies, D. S. Rajao, D. R. Perez

This paper develops a modified live influenza virus vaccine (RAM-IGIP) that enhances humoral and mucosal immunity against influenza, showing complete protection in mice.

bioRxiv · Jan 23, 2024 · PreprintImmunology

Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail (Coturnix c. japonica).

S. Carnaccini, C. J. Caceres, L. C. Gay, L. Ferreri, E. Skepner, D. F. Burke, I. H. Brown, G. Geiger, A. Obadan, D. S. Rajao, N. S. Lewis, D. R. Perez

This study maps the antigenic sites of H9 influenza A virus hemagglutinin using quail sera, identifying key amino acid substitutions that affect antigenic profiles and vaccine efficacy.

bioRxiv · May 18, 2023Microbiology

Independent evolution of influenza A virus H1N1 in pigs in Guatemala

L. Ortiz, G. Geiger, L. Ferreri, D. Moran, D. Alvarez, A. S. Gonzalez-Reiche, D. Mendez, D. S. Rajao, C. Cordon-Rosales, D. R. Perez

The paper identifies independent evolution of H1N1 influenza A viruses in Guatemalan pigs, showing distinct amino acid signatures and genetic lineage from other Central American H1N1 pdm09 viruses.

bioRxiv · Jul 21, 2022 · PreprintEvolutionary Biology

Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies

C.-Y. Lee, C. J. Caceres, G. Geiger, B. Seibert, F. C. Faccin, L. C. Gay, L. M. Ferreri, D. Kaul, J. Wrammert, G. S. Tan, D. R. Perez, A. C. Lowen

This study shows that influenza A virus escape from stem-binding antibodies incurs fitness costs, but epistatic interactions can mitigate these costs in some contexts.

bioRxiv · Jul 14, 2022 · PreprintMicrobiology

Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2

B. Seibert, C. J. Caceres, S. Carnaccini, S. Cardenas-Garcia, L. C. Gay, L. Ortiz, G. Geiger, D. S. de Souza Rajao, E. Ottesen, D. R. Perez

This study investigates SARS-CoV-2 infection in aged Golden Syrian hamsters, revealing microbiome dysbiosis and pathobiological changes similar to severe COVID-19 patients.

bioRxiv · Jul 13, 2022Microbiology

Transmission of human influenza A virus in pigs selects for adaptive mutations on the HA gene

J.-s. Mo, E. J. Abente, T. C. Sutton, L. M. Ferreri, G. Geiger, P. C. Gauger, D. R. Perez, A. L. Vincent, D. S. Rajao

This study shows that human-origin influenza A viruses can transmit in pigs and select for adaptive mutations in the HA gene that improve replication and fitness in swine hosts.

bioRxiv · Apr 4, 2022Microbiology

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

J. A. Belser, E. H. Lau, W. Barclay, I. G. Barr, H. Chen, R. A. Fouchier, M. Hatta, S. Herfst, Y. Kawaoka, S. S. Lakdawala, L. Y. Y. Lee, G. Neumann, M. Peiris, D. R. Perez, C. J. Russell, , K. M. Septer

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

bioRxiv · Apr 2, 2022Microbiology

Influenza A virus reassortment in mammals gives rise to genetically distinct within-host sub-populations

K. Ganti, A. Bagga, S. Carnaccini, L. M. Ferreri, G. Geiger, J. Caceres, B. A. Seibert, Y. Li, L. Wang, T. Kwon, Y. Li, I. Morozov, W. Ma, J. A. Richt, D. R. Perez, , A. C. Lowen

This study examines reassortment dynamics of influenza A virus in guinea pigs, ferrets, and swine, finding reassortment is common but more frequent in ferrets and guinea pigs than swine, with spatial compartmentalization observed.

bioRxiv · Feb 8, 2022 · PreprintMicrobiology

Mild and severe SARS-CoV-2 infection induces respiratory and intestinal microbiome changes in the K18-hACE2 transgenic mouse model

B. A. Seibert, J. Caceres, S. Cardenas-Garcia, S. Carnaccini, G. Geiger, D. Rajao, E. A. Ottesen, D. R. Perez

This study examines microbiome changes in K18-hACE2 mice infected with SARS-CoV-2 at different doses, finding reduced diversity and specific taxonomic shifts in the cecum but not the lung.

bioRxiv · Apr 20, 2021Microbiology