I. Singh

Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations

The paper develops STRACK to trace clonal gene expression and expansion dynamics in leukemia, showing pre-existing stem cell heterogeneity dictates clonal responses to cancer mutations.

Intrinsic epigenetic state of primary osteosarcoma drives metastasis

This study identifies chromatin activity differences in primary osteosarcoma tumors that correlate with metastatic potential and identifies genes involved in metastasis.

Mechanisms of vascular maturation and maintenance captured by longitudinal imaging of live mouse skin

This study uses longitudinal imaging to show how vascular maturation and maintenance occur in live mouse skin through vessel regression, EC rearrangement, and VEGFR2 signaling.

E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.

Regenerative Agriculture Augments Bacterial Community Structure for a Healthier Soil and Agriculture

This study compares conventional and regenerative agriculture practices, finding that regenerative methods enhance soil bacterial diversity and nutrient composition, particularly in vegetable and ragi crops.

The time to initiate retrieval of a memory depends on recency

The paper investigates how the time to retrieve a memory depends on recency, finding that response times increase logarithmically with lag, suggesting a need for temporal context recovery.

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

The paper identifies novel non-covalent and covalent inhibitors of SARS-CoV-2 main protease through virtual docking and experimental validation.

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

Autoantibody and hormone activation of the thyrotropin G protein-coupled receptor

This study determines cryogenic-electron microscopy structures of active and inactive TSHR, revealing how autoantibodies and TSH activate the receptor through similar conformational changes.

Energy Penalties Enhance Flexible Receptor Docking in a Model Cavity

The paper tests flexible receptor docking with energy penalties using MD simulations on T4 Lysozyme L99A, identifying new ligands and confirming their binding through experimental methods.

Scanning along a compressed timeline of the future

The paper introduces a novel judgment of imminence task to study future temporal order judgments and finds symmetric patterns with past memory tasks, suggesting similar underlying mechanisms.

Fine-tuning the transcriptional regulatory model of adaptation response to phosphate stress in maize (Zea mays L.)

This study identifies Pi-responsive genes in maize and proposes an updated transcriptional regulatory model for Pi starvation response.

PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2

This paper develops a triple antigen VLP vaccine candidate, PRAK-03202, against SARS-CoV-2 and shows it induces neutralizing antibodies and Th1 immune responses in mice.

Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate

The paper reports the production of a multi-antigenic SARS CoV-2 virus-like particle (VLP) in Saccharomyces cerevisiae as a vaccine candidate, confirmed by TEM and analytical data.

Microbiome disturbance and resilience dynamics of the upper respiratory tract in response to influenza A virus infection in analog hosts

The paper examines how influenza A virus infection affects the upper respiratory tract microbiome in humans and ferrets, finding that infected individuals experience microbiome disturbances that recover over time.