Author

D. Keller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. D. Jenks· 1 shared A. Garofoli· 1 shared A. Sboner· 1 shared A. Shoemark· 1 shared A. Tsalikis· 1 shared B. E. Tanos· 1 shared C. G. Toenhake· 1 shared C. K. Ng· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

A. D. Jenks

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatial modeling of telomere intra-nuclear distribution reveals non-random organization that varies during cell cycle and depends on LAP2 and BAF

D. Keller, S. Stinus, D. Umlauf, E. Gourbeyre, E. Biot, N. Olivier, P. Mahou, E. Beaurepaire, P. Andrey, L. Crabbe

The paper uses 3D imaging and spatial statistics to show telomeres have non-random distribution in nuclei, varying with cell cycle and dependent on LAP2 and BAF.

bioRxiv · Dec 22, 2022 · PreprintCell Biology

Patient-derived xenografts and organoids model therapy response in prostate cancer

S. Karkampouna, F. La Manna, M. R. De Filippo, M. Kiener, M. De Menna, E. Zoni, J. Grosjean, I. Klima, A. Garofoli, M. Bolis, J.-P. Theurillat, V. Genitsch, D. Keller, T. Booij, C. Stirnimann, , M. Kruithof-de Julio

This study develops a patient-derived xenograft (PDX) model of prostate cancer that mimics disease stages and identifies drug sensitivities in metastatic cases.

Nature Communications · Feb 18, 2021Peer-reviewedCancer Biology

The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum

E. Carrington, R. H. M. Cooijmans, D. Keller, C. G. Toenhake, R. Bartfai, T. S. Voss

The paper identifies PfAP2-HC as a heterochromatin component in Plasmodium falciparum, showing it binds heterochromatin without DNA-binding and is dependent on heterochromatin protein 1.

bioRxiv · Nov 6, 2020Microbiology

Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer

A. D. Jenks, S. Vyse, J. P. Wong, D. Keller, T. Burgoyne, A. Shoemark, M. de la Roche, A. Tsalikis, M. Michaelis, J. Cinatl, P. H. Huang, B. E. Tanos

The paper investigates how primary cilia contribute to kinase inhibitor resistance in cancer by altering cilia structure and function, leading to enhanced hedgehog pathway activation and drug resistance.

bioRxiv · Aug 25, 2017Cell Biology