Author

I. Klima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

G. N. Thalmann· 3 shared M. Kruithof-de Julio· 3 shared S. Karkampouna· 3 shared E. Zoni· 2 shared F. La Manna· 2 shared M. Kiener· 2 shared M. R. De Filippo· 2 shared M. Spahn· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

G. N. Thalmann

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3 papers

Recent·Most cited

Bladder cancer organoids as a functional system to model different disease stages and therapy response

M. Minoli, T. Cantore, M. Kiener, T. Fedrizzi, F. La Manna, S. Karkampouna, V. Genitisch, A. Rodriguez, I. Klima, P. Gasperini, B. Kiss, R. Seiler-Blarer, F. Demichelis, G. N. Thalmann, M. Kruithof-de Julio

This study uses bladder cancer patient-derived organoids to model disease stages and therapy response, identifying markers of resistance and sensitivity.

bioRxiv · Mar 31, 2022 · PreprintCancer Biology

Patient-derived xenografts and organoids model therapy response in prostate cancer

S. Karkampouna, F. La Manna, M. R. De Filippo, M. Kiener, M. De Menna, E. Zoni, J. Grosjean, I. Klima, A. Garofoli, M. Bolis, J.-P. Theurillat, V. Genitsch, D. Keller, T. Booij, C. Stirnimann, , M. Kruithof-de Julio

This study develops a patient-derived xenograft (PDX) model of prostate cancer that mimics disease stages and identifies drug sensitivities in metastatic cases.

Nature Communications · Feb 18, 2021Peer-reviewedCancer Biology

Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals conservation of bonemicroenvironment signatures

S. Karkampouna, M. R. De Filippo, C. Y. Ng, I. Klima, E. Zoni, M. Spahn, F. Stein, P. Haberkant, G. N. Thalmann, M. Kruithof-de Julio

The paper identifies tenascin C as a stromal marker associated with metastasis in prostate cancer xenograft models and shows its prognostic potential in patient samples.

bioRxiv · Apr 3, 2020Cancer Biology