M. Michaelis

Resistance patterns in drug-adapted cancer cell lines reflect complex evolution in clinical tumors

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

A flexible loop in the paxillin LIM3 domain mediates direct binding to integrin β3

This study identifies a direct interaction between paxillin and integrin β3 cytoplasmic tail via a flexible loop in the LIM3 domain, revealing an alternative signaling pathway.

Repurposing of the antibiotic nitroxoline for the treatment of mpox

This study shows nitroxoline, an antibiotic, inhibits mpox virus replication and remains effective against tecovirimat-resistant strains, suggesting it as a repurposing candidate for mpox treatment.

Omicron-induced interferon signalling prevents influenza A virus infection

This study shows Omicron variants induce interferon responses in human cells, protecting against influenza A virus super-infection, while Delta does not.

Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants

This study evaluates the antiviral efficacy of interferon-beta combined with antiviral drugs against SARS-CoV-2 variants, finding synergistic effects with certain drugs against specific variants.

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

This study develops a phenotypic screening platform using caspase 3/7 activity to identify antiviral compounds against SARS-CoV-2, including novel candidates and combinations.

SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment

This study shows that SARS-CoV-2 Omicron variants are more sensitive to interferon treatment than Delta variants, suggesting interferons could be effective therapies for Omicron infections.

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant SARS-CoV-2 isolates

This study compares drug sensitivity and interferon antagonism between Omicron and Delta SARS-CoV-2 variants, finding similar drug responses but reduced interferon antagonism in Omicron.

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

Multifaceted roles of SAMHD1 in cancer

This study analyzes SAMHD1's role in cancer using TCGA and TARGET databases, finding no consistent tumour suppressor effect and suggesting context-dependent pro-or anti-tumourigenic effects.

CD47 as a potential biomarker for the early diagnosis of severe COVID-19

This study identifies CD47 as a potential biomarker for early diagnosis of severe COVID-19 by showing its increased levels in SARS-CoV-2 infection and association with risk factors and complications.

Data variability in standardised cell culture experiments

The paper analyzes variability in drug response data from standardized cell culture experiments and finds high intrinsic variability even among well-controlled experiments.

Targeting pentose phosphate pathway for SARS-CoV-2 therapy

This study identifies the pentose phosphate pathway as a target for SARS-CoV-2 therapy and shows that inhibiting it with benfooxythiamine reduces viral replication.

COVID-19-related coagulopathy, is transferrin a missing link?

The paper identifies transferrin as a potential coagulation promoter in COVID-19, showing age-related increases, sex differences, and upregulation upon infection.

SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles

This study compares SARS-CoV-2 and SARS-CoV in cell tropism and drug sensitivity, finding differences in conservation, receptor usage, and therapeutic responses to aprotinin and remdesivir.

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.

The paper identifies two prognostic cervical squamous cell carcinoma subtypes across three continents, revealing conserved molecular and immune features.

Drug-adapted cancer cell lines reveal drug-induced heterogeneity and enable the identification of biomarker candidates for the acquired resistance setting

The paper investigates drug-induced heterogeneity in cancer cell lines and identifies biomarkers for acquired resistance to YM155.

Testing of the survivin suppressant YM155 in a large panel of drug-resistant neuroblastoma cell lines

This study tests YM155 in 101 neuroblastoma cell lines, revealing ABCB1 and ABCC1 as mediators of resistance and highlighting cross-resistance differences between drug-adapted lines.

A novel exosome biogenesis mechanism: multivesicular structures budding and rupturing at the plasma membrane

The paper identifies a novel exosome release mechanism where multivesicular structures protrude from the plasma membrane and rupture to release exosomes, distinct from the conventional multivesicular endosome fusion process.

The thrombopoietin receptor agonist eltrombopag inhibits human cytomegalovirus replication via iron chelation

This paper shows eltrombopag inhibits HCMV replication via iron chelation, effective against drug-resistant strains and synergistic with ganciclovir.

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance

This study shows that doxorubicin-loaded human serum albumin nanoparticles enhance anti-cancer activity in drug-resistant neuroblastoma cells by bypassing ABCB1-mediated efflux.

Elevated expression of LGR5 and WNT signalling factors in neuroblastoma cells with acquired drug resistance

This study shows that LGR5 and WNT signaling factors are elevated in neuroblastoma cell lines with acquired drug resistance, suggesting a role for the WNT pathway in resistance mechanisms.

Incorporation of doxorubicin in different polymer nanoparticles and their anti-cancer activity

This study compares the anti-cancer activity of doxorubicin-loaded nanoparticles made from different polymers and preparation methods, finding significant differences in efficacy based on size, drug load, and release kinetics.

Drug repurposing: omeprazole increases the efficacy of acyclovir against herpes simplex virus type 1 and 2

This paper shows that omeprazole enhances acyclovir's effectiveness against herpes simplex virus 1 and 2 in cell cultures without harming cell viability.

Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer

The paper investigates how primary cilia contribute to kinase inhibitor resistance in cancer by altering cilia structure and function, leading to enhanced hedgehog pathway activation and drug resistance.

A Cell Culture Platform For Cryptosporidium That Enables Long-Term Cultivation And New Tools For The Systematic Investigation Of Its Biology