Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs
A. Lorzadeh, C. Hammond, D. Knapp, Q. Cao, F. Wang, A. Heravi-Moussavi, M. Wong, M. Bilenky, M. Moksa, Z. Sharafianardakani, P. Lavoie, C. Eaves, M. Hirst
The paper shows that H3K27me3 chromatin state changes are critical for terminal differentiation in human hematopoiesis, being retained in lymphoid cells but lost in monocytes and erythroblasts.
bioRxiv · Jun 4, 2020Cell Biology