Author

C. Hammond

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:differential expression· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

C. J. Eaves· 2 shared D. Bergen· 2 shared D. Stephens· 2 shared F. Wang· 2 shared M. Hirst· 2 shared N. Stevenson· 2 shared A. Heravi-Moussavi· 1 shared A. Koren· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

C. J. Eaves

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Author profile →

5 papers

Recent·Most cited

Human lymphoid-neutrophil/monocyte restriction co-ordinately activates increased proliferation despite parallel heterogeneity in transcriptional changes

F. Wang, L. G. Campos, C. Hammond, M. Hirst, B. D. Simons, C. J. Eaves

The paper identifies shared proliferation acceleration and heterogeneous transcriptional changes during B-lymphoid and neutrophil/monocyte lineage restriction from CD34+ cord blood cells.

bioRxiv · Feb 18, 2024 · PreprintImmunology

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs

A. Lorzadeh, C. Hammond, D. Knapp, Q. Cao, F. Wang, A. Heravi-Moussavi, M. Wong, M. Bilenky, M. Moksa, Z. Sharafianardakani, P. Lavoie, C. Eaves, M. Hirst

The paper shows that H3K27me3 chromatin state changes are critical for terminal differentiation in human hematopoiesis, being retained in lymphoid cells but lost in monocytes and erythroblasts.

bioRxiv · Jun 4, 2020Cell Biology

Replication timing alterations in leukemia reflect stable clinically-relevant changes in genome architecture

J. C. Rivera-Mulia, T. Sasaki, C. Trevilla-Garcia, N. Nakamichi, D. J. H. F. Knapp, C. Hammond, B. Chang, J. W. Tyner, M. Devidas, J. Zimmerman, K. Klein, V. Somasundaram, B. Druker, T. Gruber, A. Koren, , D. M. Gilbert

The paper compares DNA replication timing profiles of BCP-ALL leukemic samples with normal B-lineage differentiation stages to identify clinically relevant features.

bioRxiv · Apr 11, 2019 · PreprintCancer Biology

Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control

N. Stevenson, D. Bergen, A. Xu, E. Wyatt, F. Henry, J. McCaughey, L. Vuolo, C. Hammond, D. Stephens

The paper identifies RCAN2 as a regulator of cilia length that compensates for loss of giantin function in ciliogenesis.

bioRxiv · Apr 4, 2018Cell Biology

Giantin knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression.

N. Stevenson, D. Bergen, R. Skinner, E. Kague, E. Martin-Silverstone, K. Robson Brown, C. Hammond, D. Stephens

Giantin knockout in cell lines and zebrafish alters glycosyltransferase expression, revealing Golgi regulation of proteoglycome function.

bioRxiv · Oct 19, 2017Cell Biology