M. Moksa

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming

This study examines the epigenomic states of synovial sarcoma using multi-omics analysis, revealing a continuum of epigenomic states and identifying H3K4me3 inhibition as a potential therapeutic strategy.

Global prediction of candidate R-loop binding and R-loop regulatory proteins

The paper develops a random forest classifier to predict R-loop binding proteins using proteomic features and amino acid composition, and validates new R-loop modulating proteins through CRISPR screening.

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs

The paper shows that H3K27me3 chromatin state changes are critical for terminal differentiation in human hematopoiesis, being retained in lymphoid cells but lost in monocytes and erythroblasts.

The pathognomonic FOXL2 C134W mutation alters DNA binding specificity

This study investigates the molecular effects of the FOXL2 C134W mutation in AGCT by analyzing DNA binding and transcriptome changes in engineered cell lines.

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

This study compares MeCP2-E1 and E2 isoforms, showing differences in DNA binding, protein interactions, and dynamic behavior, with implications for their functional roles in chromatin regulation.