Q. Cao

Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction

This study examines the evolution of the resistome in Salmonella Gallinarum during its transition to endemicity, revealing localized mobilome-driven resistance profiles.

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming

This study examines the epigenomic states of synovial sarcoma using multi-omics analysis, revealing a continuum of epigenomic states and identifying H3K4me3 inhibition as a potential therapeutic strategy.

Cardiac Localized Polycystin-2 plays a Functional Role in Natriuretic Peptide Production and its Absence Contributes to Hypertension

This study shows that cardiac polycystin-2 is involved in natriuretic peptide production, and its absence leads to hypertension in ADPKD mice.

Utilization of the genetically encoded calcium indicator Salsa6F in cardiac applications

The paper evaluates the use of the genetically encoded calcium indicator Salsa6F in cardiac applications, comparing it to Fluo-4AM and demonstrating its utility in measuring calcium transients in cardiomyocytes and heart preparations.

Virus-derived circular RNAs populate hepatitis C virus-infected cells

The paper identifies virus-derived circular RNAs (vcircRNAs) in hepatitis C virus-infected cells, showing they enhance viral RNA abundance and promote translation of novel viral proteins.

The central nervous system is a potential reservoir and possible origin of drug resistance in HBV

This study finds HBV can persist in cerebrospinal fluid, showing distinct mutations and resistance patterns compared to serum, and HIV co-infection increases resistance mutations in both compartments.

Implantable flexible multielectrode arrays for multi-site sensing of serotonin tonic levels

This paper develops implantable flexible microelectrode arrays for chronic in vivo measurement of tonic serotonin levels across multiple brain sites in mice.

Heterotrophic bacteria drive sulfide oxidation in coastal sediments

This study identifies heterotrophic bacteria as key drivers of sulfur oxidation in coastal sediments and seawater by analyzing microbial communities and metagenomes.

Synthetic extremophiles: Species-specific formulations for microbial therapeutics and beyond.

The paper develops synthetic extremophiles to enhance microbial viability under extreme conditions, demonstrating stability improvements for key industrial organisms.

Multi-Omic Analysis of Tyrophagus putrescentiae Reveals Insights into the Allergen Complexity of Storage Mites

This study reveals a comprehensive allergen profile of Tyrophagus putrescentiae using multi-omic approaches, identifying 37 allergen groups and five novel allergens.

The porcine cGAS-STING pathway exerts an unusual antiviral function independent of IFN and autophagy

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

Single-cell analysis reveals the range of transcriptional states of circulating human neutrophils

This study uses scRNA-seq to show that circulating human neutrophils are transcriptionally heterogeneous, forming four distinct clusters with distinct transcriptional states.

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

The paper presents a cryo-EM structure of RNA-bound tau fibrils, revealing a small C-terminal core that may nucleate fibril formation and is essential for fibril integrity.

Barley stripe mosaic virus γb protein targets thioredoxin h-type 1 to dampen SA-mediated antiviral defenses

The paper shows that BSMV γb protein targets NbTRXh1 to reduce its reductase activity, impairing SA defense gene expression and enhancing viral movement.

Sulfane sulfur post-translationally modifies the global regulator AdpA to influence actinorhodin production and morphological differentiation of Streptomyces coelicolor

The paper identifies sulfane sulfur-mediated post-translational modification of AdpA in Streptomyces coelicolor, enhancing actinorhodin production and morphological differentiation.

RPRM negatively regulates ATM levels involving its phosphorylation mediated by CDK4/CDK6

This study identifies RPRM as a negative regulator of ATM levels through phosphorylation by CDK4/6, enhancing cellular sensitivity to genotoxic agents and radiation.

Different structures and pathologies of alpha-synuclein fibrils derived from preclinical and postmortem patients of Parkinson's disease

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

MiR-384 Regulates Reelin by Inhibiting ADAMTS4 in Neuronal Cell Lines

The paper investigates miR-384's role in regulating Reelin by inhibiting ADAMTS4 in neuronal cell lines, showing reduced ADAMTS4 and Reelin fragments with miR-384 overexpression.

African swine fever virus structural protein p17 inhibits cGAS-STING signaling pathway through interacting with STING

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

Honeybee gut microbiota modulates host behaviors and neurological processes

This study shows that honeybee gut microbiota influences olfactory learning, brain neurotransmitter levels, and metabolism, with parallels to human autism-related gene expression.

An Adhesive Based Fabrication Technique for Culture of Lung Airway Epithelial Cells with Applications in Microfluidics and Lung on a Chip

This paper introduces a cost-effective cell culture method using pressure-sensitive adhesives for growing lung airway epithelial cells on porous membranes, enabling transfer to microfluidic chips for further analysis.

Transcriptome Profiling of different types of human respiratory tract cells infected by SARS-CoV-2 Highlight an unique Role for Inflammatory and Interferon Response

This study identifies 36 upregulated genes across SARS-CoV-2-infected respiratory tract cells, highlighting inflammatory and interferon response pathways linked to cytokine storms in severe COVID-19.

Development and validation of an open-source, disposable, 3D-printed in vitro environmental exposure system for Transwell culture inserts

The paper develops and validates an open-source 3D-printed in vitro system to study cannabis smoke exposure on human airway epithelial cells, showing changes in morphology and cytokine expression without significant cytotoxicity.

LPA/PKD-1 signaling promotes development of arteriolar niche that supports self-renewal of breast cancer stem cells and stemness

A novel copper-sensing two-component system for activating Dsb genes in bacteria

The paper identifies a novel copper-sensing two-component system, DsbRS, in Pseudomonas aeruginosa that activates the dsbDEG operon involved in copper resistance.

Epigenetic Interaction between UTX and DNMT1 Regulates Diet-Induced Myogenic Remodeling in Brown Fat

The paper shows that the interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat by maintaining brown adipocyte identity and thermogenic function.

Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue

This study identifies NTF3 as a fat-derived neurotrophic factor that regulates sympathetic innervation and thermogenesis in adipose tissue, influencing energy metabolism and obesity.

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs

The paper shows that H3K27me3 chromatin state changes are critical for terminal differentiation in human hematopoiesis, being retained in lymphoid cells but lost in monocytes and erythroblasts.

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

This study determines the cryo-EM structure of human IAPP fibrils and designs inhibitors to delay aggregation, offering insights into T2D pathology and therapeutic strategies.