Structural Basis of Prostaglandin Efflux by MRP4
S. Pourmal, E. Green, R. Bajaj, I. Chemmama, G. Knudsen, M. Gupta, A. Sali, Y. Cheng, C. Craik, D. Kroetz, R. Stroud
This study determines the cryo-EM structures of MRP4 bound to prostaglandins and DHEA-S, revealing its unique substrate specificity and transport mechanism.
bioRxiv · Dec 22, 2022Biochemistry