M. Gupta

The progression of neurovascular features and chemokine signatures of the intervertebral disc with degeneration

This study tracks the temporal changes in chemokine production and neurovascular invasion in mouse intervertebral discs during degeneration following injury.

Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized

This study examines oral microbiomes of Nepali individuals with different lifestyles, finding that lifestyle, not geography, shapes microbiome composition across a gradient from foraging to industrialized.

Structural basis of autoantibody binding in Neuromyelitis Optica

This study determines the structural basis of autoantibody binding to aquaporin-4 in NMO, revealing epitope diversity on tetrameric and higher-order assemblies.

Impact of Species-Specific Plant Growth-Promoting Rhizobacteria (PGPR) on Maize (Zea mays) Phenotypic and Biochemical Diversity

This study evaluates the impact of four PGPR species on maize growth and biochemical parameters, finding significant increases in chlorophyll, enzymes, and yield.

Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease

The paper traces the evolution of autoantibodies in HCV-CV patients, revealing convergent somatic mutations and compromised solubility in pathogenic B cells.

ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function

This study classifies ADPKD-causing missense variants in polycystin-1 into two categories based on their effects on cell surface localization or ion channel function and suggests small-molecule therapies.

Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutamate export and glutaminase

This study shows that inhibiting glutaminase and xCT in TNBC disrupts redox balance, enhances chemotherapy efficacy, and can be monitored non-invasively using PET.

PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

This study shows PfMORC regulates chromatin structure and gene repression in Plasmodium falciparum, essential for parasite survival and a potential target for antimalarial drugs.

Partnership with both fungi and bacteria can protect Odontotermes obesus fungus gardens against fungal invaders.

This study identifies pathogenic fungi in termite fungus gardens and shows that interactions with bacteria and the crop fungus help maintain a Termitomyces monoculture.

Multitask Learning of Longitudinal Circulating Biomarkers and Clinical Outcomes: Identification of Optimal Machine-Learning and Deep-Learning Models

This study evaluates machine learning and deep learning models for predicting clinical outcomes using high-dimensional longitudinal biomarker data from a lung cancer trial, finding that MFPCA-Cox outperforms other methods.

Pharmacological Studies on the Efficacy of a Polyherbal Formulation Dawa ul kurkum in DEN-Induced 2-AAF-Promoted Hepatocellular Carcinoma in Male Wistar Rats

This study evaluates the anti-cancer effects of Dawa-ul kurkum in DEN-induced hepatocarcinoma in rats, showing reduced oxidative stress and restored liver function.

A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit

The paper describes the molecular mechanism of microtubule bundle assembly and disassembly during quiescence exit in yeast.

Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

The paper identifies type I interferon dynamics as a key factor shaping memory B cell development during chronic viral infection and shows that early IFNAR-1 blockade can reverse chromatin changes.

Anthelmintic efficacy of Holarrhena pubescens against Raillietina spp. of domestic fowl through ultrastructural, histochemical, biochemical and GLCM analysis

This paper evaluates the anthelmintic effects of Holarrhena pubescens extracts on Raillietina spp. using ultrastructural, histochemical, biochemical, and GLCM analysis, finding the ethyl acetate fraction most effective.

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

The paper identifies epigenetic inhibitors active against Plasmodium vivax hypnozoites through drug repurposing screens, showing epigenetic pathways are critical for hypnozoite quiescence.

Structural Basis of Prostaglandin Efflux by MRP4

This study determines the cryo-EM structures of MRP4 bound to prostaglandins and DHEA-S, revealing its unique substrate specificity and transport mechanism.

Profiling of the β-glucosidases identified in the genome of Penicillium funiculosum: Insights from genomics, transcriptomics, proteomics and homology modelling studies

This study profiles β-glucosidases in Penicillium funiculosum using genomics, transcriptomics, proteomics, and molecular dynamics, identifies key enzymes, and improves thermostability through protein engineering.

Identification and Characterization of Probiotics Isolates from Indigenous Chicken (Gallus domesticus) of Nepal

The paper isolates and characterizes potential probiotic bacteria from indigenous chickens in Nepal, identifying four Lactobacillus strains with probiotic properties.

Spatial structure alters the site frequency spectrum produced by hitchhiking

This study shows spatial structure changes the site frequency spectrum from hitchhiking, revealing distinct frequency regimes near and far from a selective sweep.

Decoding The Nuclear Genome of The Human Pathogen Babesia duncani Shed Light on its Virulence, Drug Susceptibility and Evolution among Apicomplexa

This study decodes the nuclear genome of Babesia duncani, identifies virulence factors and drug targets, and discovers potent inhibitors for treating babesiosis.

Critical Mechanistic Features of HIV-1 Viral Capsid Assembly

This study uses simulations to show IP6 promotes conical HIV-1 capsid formation by stabilizing curvature and shifting assembly kinetics.

Inositol hexakisphosphate (IP6) accelerates immature HIV-1 Gag protein assembly towards kinetically-trapped morphologies

This study uses simulations to show IP6 accelerates HIV-1 Gag assembly, promoting curvature and defects that may aid viral morphogenesis.

The HIV latency reversal agent HODHBt enhances NK Cell effector and memory-like functions by increasing IL-15 mediated-STAT activation

This paper shows that HODHBt enhances NK cell effector and memory-like functions by boosting IL-15-mediated STAT activation, leading to increased cytotoxicity and cytokine secretion.

Symmetry reduction in a hyperpolarization-activated homotetrameric ion channel

The paper determines the structure of the hyperpolarization-activated channel AKT1 from Arabidopsis thaliana and shows it undergoes symmetry reduction to regulate electrical activation.

Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division

This study shows OPTN regulates bacterial invasion by linking HACE1-mediated Rac1 ubiquitylation to integrin mechanotransduction and ECM stiffness.

Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8+ T cells

The paper identifies progenitor cells of T-cell exhaustion in acute HCV infection and shows their functional and phenotypic characteristics.

Nanoparticle-mediated transgene expression of insulin-like growth factor 1 in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations

This study uses nanoparticle-mediated hIGF-1 gene therapy in a guinea pig model of FGR to increase placental nutrient transporter expression and fetal glucose concentrations.

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.

Bacillus anthracis chain length, a virulence determinant, is regulated by a transmembrane Ser/Thr protein kinase PrkC

This study identifies PrkC, a transmembrane Ser/Thr kinase in B. anthracis, as a regulator of bacterial chain length, which impacts virulence and pathophysiological outcomes.