Y. Cheng

Nonlinear compliance of NompC gating spring and its implication in mechanotransduction

The paper measures the mechanical properties of NompC gating springs and finds nonlinear compliance that may regulate mechanotransduction sensitivity.

Impacts of global warming on fertility of male fishes: evidence from meta-analysis of temperature effects on spermatozoa motility

This study uses a meta-analysis of 20 fish species to show that increased water temperature reduces sperm motility and related parameters in cold-water species more than in warm-water species.

Biophysical Profiling of Red Blood Cells from Thin-film Blood Smears using Deep Learning

This paper develops a deep learning model to detect RBC deformability and storage-related changes in blood smears, showing high accuracy in categorizing deformability groups.

Structure and function of an intermediate GPCR-G protein complex

The paper resolves the structure of an intermediate GPCR-G protein complex and shows it initiates nucleotide exchange without progressing to the fully activated state, providing insights into GPCR signaling complexity.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Protocatechuic acid induces endogenous oxidative stress in CR-hvKP by regulating the EMP-PPP pathway

This study shows that protocatechuic acid (PCA) enhances antibiotic efficacy against carbapenem-resistant hypervirulent Klebsiella pneumoniae by inducing oxidative stress through regulation of the EMP-PPP pathway.

Systematic mapping of MCU-mediated mitochondrial calcium signaling networks

This study maps the MCU-mediated mitochondrial calcium signaling network using proteomics, identifying 89 new interactors and their roles in disease-related pathways.

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

Dendritic cell-derived lncRNA in patients with acute coronary syndrome

This study examines lncRNA expression in monocyte-derived dendritic cells (moDC) across different ACS subtypes, identifying CCL15-CCL14 as a differentially expressed lncRNA that modulates moDC function.

Individual recognition in a jumping spider (Phidippus regius)

This study shows jumping spiders can recognize individual identities through long-term memory, challenging the assumption that only vertebrates with larger brains have this ability.

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein

This study shows that the truncated N* variant of SARS-CoV-2 nucleocapsid protein can assemble into vRNPs similar to full-length N, requiring the leucine-rich helix and inhibited by a phosphomimetic SR region.

Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

Late-life Rapamycin Treatment Enhances Cardiomyocyte Relaxation Kinetics and Reduces Myocardial Stiffness

This study shows that late-life rapamycin treatment improves cardiomyocyte relaxation and reduces myocardial stiffness in aged mice, reversing diastolic dysfunction.

Lymphoid tissues contribute to viral clonotypes present in plasma at early post-ATI in SIV-infected rhesus macaques

This study identifies secondary lymphoid tissues as a source of SIV clonotypes detected in plasma early after antiretroviral therapy interruption.

Synchrony of Bird Migration with Avian Influenza Global Spread; Implications for Vulnerable Bird Orders

The paper uses phylodynamic analyses to link bird migration patterns with the global spread of HPAIV H5 clade 2.3.4.4, identifying vulnerable bird orders and highlighting Suliformes and Ciconiiformes as important in virus dispersal.

Enhancing anti-gastrointestinal cancer activities of CLDN18.2 CAR-T armored with novel synthetic NKG2D receptors Containing DAP10 and DAP12 signaling domains.

This paper develops a CAR-T therapy for gastrointestinal cancers by combining CLDN18.2 targeting with synthetic NKG2D receptors containing DAP10 and DAP12 domains, improving efficacy against heterogeneous tumors.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

Structural basis of TRPV1 modulation by endogenous bioactive lipids

This study identifies a lipid-binding pocket in TRPV1 and shows that its occupancy by phosphoinositides modulates channel activity, with lipid ejection triggering activation.

eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

The paper identifies eIF3k as a regulator of ribosome content in cancer by showing its depletion increases global translation and stress resistance through repression of RPS15A synthesis.

Self-regulatory function of bacterial small heat shock protein IbpA through mRNA binding is conferred by a conserved arginine

This study identifies a conserved arginine residue in IbpA that mediates its self-repression of translation via mRNA binding, while preserving its chaperone activity.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma

The paper identifies NDC80 as a predictor of ccRCC progression and shows that NDC80-high tumors are sensitive to mitotic kinase inhibitors.

Modelling drug responses and evolutionary dynamics using triple negative breast cancer patient-derived xenografts

This paper uses TNBC patient-derived xenografts to model drug responses and evolutionary dynamics, revealing a novel mechanism of olaparib response and synergistic effects with salinomycin.

Harnessing antimicrobial peptide genes to expedite disease-resistant enhancement in aquaculture: Transgenesis and genome editing

This study evaluates the use of antimicrobial peptide genes in aquaculture through meta-analysis and CRISPR/Cas9 systems to enhance disease resistance in fish.

Structural Basis of Prostaglandin Efflux by MRP4

This study determines the cryo-EM structures of MRP4 bound to prostaglandins and DHEA-S, revealing its unique substrate specificity and transport mechanism.

Leptospermum extract (QV0) suppresses pleural mesothelioma tumour growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis

This study shows that Leptospermum extract (QV0) reduces pleural mesothelioma tumour growth in vitro and in vivo by inducing mitochondrial dysfunction and apoptosis without adverse effects.

Taming the data deluge: a novel end-to-end deep learning framework for classifying marine biological and environmental images

The paper introduces a deep learning framework that improves classification of marine images by using scene classification to enhance accuracy in diverse underwater environments.

Manipulating Oxalate Decarboxylase Provides the Basis of Antilithic Therapy by Acting on the Gut Microbiota

The paper identifies Zn2+ as a therapeutic agent for calcium oxalate kidney stones by enhancing oxalate-degrading bacteria and their enzymes in the gut microbiota.