Exploiting evolutionary trade-offs to combat antibiotic resistance
S. V. Melnikov, D. L. Stevens, X. Fu, H. S. Kwok, J.-T. Zhang, Y. Shen, J. Sabina, K. Lee, H. Lee, D. Soll
The paper demonstrates that antibiotic-resistant cells can be inhibited by exploiting fitness trade-offs using norvaline to target genetic mutations in leucyl-tRNA synthetase in tavaborole-resistant E. coli.
bioRxiv · Jan 20, 2020 · PreprintEvolutionary Biology