Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities
C. Campbell, D. Lewis-Smith, C. Leu, H. Martins, S. Wolking, R. Krause, T. J. O'Brien, G. Sills, F. Zara, B. P. Koeleman, C. Depondt, A. Marson, H. Stefansson, K. Stefansson, J. Craig, , G. Cavalleri
This study uses polygenic risk scores to show that people with epilepsy have increased genetic risk for depression, psychosis, and ADHD, with stronger associations in drug-resistant cases.
medRxiv · Jul 4, 2023 · PreprintGenetic & Genomic Medicine