C. Campbell

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

This study shows NCOR1 regulates Treg cell differentiation and suppressive function by maintaining transcriptional integrity in both naive and effector states.

Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities

This study uses polygenic risk scores to show that people with epilepsy have increased genetic risk for depression, psychosis, and ADHD, with stronger associations in drug-resistant cases.

Organometallic Pillarplexes that bind DNA 4-way Holliday Junctions and Forks.

This paper demonstrates that Au pillarplexes bind open DNA 4-way junctions and rearrange them into Y-shaped forks, with antiproliferative activity in human cells.

Bacterial anomalies in seabed sediments associated with deep water hydrocarbon seepage

This study uses 16S rRNA gene sequencing to identify bacterial anomalies in deep-sea sediments linked to hydrocarbon seepage, finding distinct microbial signatures associated with thermogenic and biogenic hydrocarbons.

Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics

This study shows that purine nucleosides like guanosine and xanthosine reduce β-lactam resistance in MRSA by lowering c-di-AMP levels, acting as adjuvants to restore antibiotic effectiveness.

Geological processes mediate a subsurface microbial loop in the deep biosphere

The paper investigates a subsurface microbial loop mediated by geological processes, showing thermophilic endospores migrate from deep oil reservoirs to the seabed and re-enter the geosphere through sedimentation.

The immunophilin protein FKBPL and its peptide derivatives are novel regulators of vascular integrity and inflammation via NF-kappaB signaling

This paper identifies FKBPL and its peptides as regulators of vascular integrity and inflammation via NF-kappaB signaling, showing therapeutic potential in inflammatory diseases.

The chromosomal passenger complex establishes chromosome biorientation via two parallel localization pathways

This study identifies two parallel pathways by which the CPC establishes chromosome biorientation in budding yeast through distinct localization mechanisms.

An analysis of genetic diversity actions, indicators and targets in 114 National Reports to the Convention on Biological Diversity

This study quantitatively analyzes genetic diversity actions, indicators, and targets in 114 CBD National Reports, finding limited focus on wild species and inadequate monitoring indicators.

Impaired alanine transport or exposure to D-cycloserine increases the susceptibility of MRSA to beta-lactam antibiotics

The paper shows that impairing alanine transport or exposing MRSA to D-cycloserine increases susceptibility to beta-lactam antibiotics by reducing peptidoglycan crosslinking.

A quantitative evaluation of MIRU-VNTR typing against whole-genome sequencing for identifying Mycobacterium tuberculosis transmission: A prospective observational cohort study

This study evaluates MIRU-VNTR typing against whole-genome sequencing to identify Mycobacterium tuberculosis transmission, finding low predictive value of MIRU-VNTR and lineage-specific performance.