R. Krause

A novel ionic model for matured and paced atrial-like hiPSC-CMs integrating IKur and IKCa currents

This paper develops an atrial-specific in-silico model of stem cell-derived cardiomyocytes integrating IKur and IKCa currents, validated against experimental data to improve drug testing and understanding of atrial fibrillation.

Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities

This study uses polygenic risk scores to show that people with epilepsy have increased genetic risk for depression, psychosis, and ADHD, with stronger associations in drug-resistant cases.

Adaptation of a transmitted/founder simian-human immunodeficiency virus for enhanced replication in rhesus macaques

This paper adapts a transmitted/founder SHIV to enhance replication in rhesus macaques while preserving HIV-1 Env biology, resulting in a more fit virus for NHP HIV studies.

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

A pipeline to track unlabeled cells in wide migration chambers using pseudofluorescence

The paper describes a deep learning-based pipeline that converts transmitted light signals from unlabeled cells into pseudofluorescence to improve tracking accuracy and duration in 3D migration chambers.

Mycobacterium tuberculosis senses host Interferon- gamma via the membrane protein MmpL10

This study shows Mycobacterium tuberculosis senses IFN-γ via MmpL10, increasing respiration and virulence, and enhances INH efficacy against persistent bacteria.