Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes
K. C. Mudumbi, E. A. Burns, D. J. Schodt, Z. O. Petrova, A. Kiyatkin, L. W. Kim, E. M. Mangiacapre, I. Ortiz-Caraveo, H. R. Ortiz, C. Hu, K. D. Ashtekar, K. A. Lidke, D. Lidke, M. A. Lemmon
This study investigates how EGFR dimers and higher-order oligomers form and interact in cell membranes using SPT and FRET, revealing the role of the tyrosine kinase domain in oligomerization.
bioRxiv · Apr 10, 2023Biophysics