G. Phillips

Heterotrimeric Collagen Helix with High Specificity of Assembly Results in a Rapid Rate of Folding

This paper designs a collagen heterotrimer with high folding specificity and reports its faster folding rate compared to other systems.

Post-translational Modification of α-Synuclein Modifies Monomer Dynamics and Aggregation Kinetics

This study examines how O-GlcNAcylation at T72 and S87 of α-synuclein affects its monomer dynamics and aggregation kinetics, revealing differential impacts on protein behavior.

Large-bodied ornithomimosaurs inhabited Appalachia during the Late Cretaceous of North America

This paper describes large-bodied ornithomimosaurs from the Late Cretaceous of Appalachia, revealing coexistence of medium- and large-sized species in North America.

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature

This study determines the crystal structures of SARS-CoV-2 NSP3 macrodomain using neutron and X-ray diffraction, revealing insights into its catalytic mechanism and ligand binding.

RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy

The paper shows that GDC-0077 and taselisib degrade mutant PI3K alpha via HER2-dependent mechanisms, enhancing efficacy in PIK3CA-mutant breast cancer.

Inhibitor Binding Modulates Protonation States in the Active Site of SARS-CoV-2 Main Protease

This study uses neutron crystallography to show that inhibitor binding changes protonation states of three histidine residues in SARS-CoV-2 Mpro, providing insights for drug design.

Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL

The paper directly observes fast ligand binding in a biomedically relevant enzyme using MHz X-ray pulses at the European XFEL.

Protonation states in SARS-CoV-2 main protease mapped by neutron crystallography

This study determines the protonation states of SARS-CoV-2 main protease using neutron crystallography, revealing a zwitterionic active site with specific charge states of key residues.

Ebselen Reacts with SARS Coronavirus-2 Main Protease Crystals

This paper shows that Ebselen inhibits SARS-CoV-2 main protease 3CLpro by destroying its crystal diffraction power, suggesting it as a potential antiviral agent.

Compositional shifts in the root microbiota track the life-cycle of field-grown rice plants

This study tracks root microbiota changes in field-grown rice over its life cycle, showing dynamic shifts during the vegetative phase and correlations with developmental stages rather than age alone.

Differential Mast Cell Outcomes Are Sensitive to FcϵRI-Syk Binding Kinetics

The paper uses single molecule imaging to study FcϵRI-Syk binding dynamics in mast cells, showing that altered binding kinetics affect signaling outcomes.