C. Hu

Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

This study identifies a zebrafish model of IBD by knocking out Ctla-4, showing similar intestinal inflammation and immune dysregulation to mammalian IBD.

Light-induced Extracellular Vesicle Adsorption

This paper introduces LEVA, a label-free, high-resolution, tunable platform for EV adsorption and characterization, demonstrating its versatility with various EV sources and applications.

Flow zoometry of Drosophila

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

An interpretable integration model improving disease-free survival prediction for gastric cancer based on CT images and clinical parameters

This paper proposes a model integrating deep features, radiomics features, and clinical parameters to improve gastric cancer disease-free survival prediction, achieving a 3%-5% C-index and 10% AUC improvement.

The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells

This study shows PGE2 inhibits glucose-stimulated insulin secretion in β-cells via the EP2/4-Kv2.2 pathway by modulating Kv2.2 channels through PKA.

TLR9 activation in large wound induces tissue repair and hair follicle regeneration via gamma delta T cells

This study shows that TLR9 activation in wounds promotes tissue repair and hair follicle regeneration through gamma delta T cells by increasing AREG production and modulating keratinocyte fate.

Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer

This study identifies a novel feed-forward signalling axis between PEAK1 and CAMK2 in TNBC, showing that targeting CAMK2 can inhibit PEAK1-driven oncogenic processes.

Using split protein reassembly strategy to control PLD enzymatic activity

This study uses split protein reassembly and optogenetic techniques to control PLD enzymatic activity by modulating domain interactions.

CRISPR-repressed toxin-antitoxin provides population-level immunity against diverse anti-CRISPR elements

The paper identifies a CRISPR-repressed toxin that provides population-level immunity against diverse anti-CRISPR elements by expelling them through abortive infection-like effects.

Climate change impacts dryland multifunctionality: A cascade of precipitation variability to species replacement in multitrophic microbiota

This study examines how precipitation variability impacts soil multifunctionality in drylands through changes in microbial communities, revealing cascading effects on ecosystem function.

Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

This study uses single-cell RNA sequencing to show zebrafish kidney cells can generate both blood cells and adaptive antiviral immunity, acting as a dual-functional organ.

Evolution of gene expression across brain regions in behaviorally divergent deer mice

This study examines gene expression differences across brain regions in two deer mouse species and their hybrids, finding widespread interspecific variation and regional modularity in gene regulation.

Metabolites with benzene ring from sugarcane leaf play important role in plant-Spodoptera frugiperda interaction

The paper identifies benzene-ring containing metabolites in sugarcane that influence Spodoptera frugiperda behavior and development, with some promoting insect growth and others repelling them.

Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications

This study defines the DNA binding and cleavage mechanisms of Type I-C CRISPR-Cas3 using cryo-EM and identifies anti-CRISPR proteins that inhibit its activity in human cells.

Immuno-Engineered Mitochondria for Efficient Therapy of Acute Organ Injuries via Modulation of Inflammation and Cell Repair

This study develops nMITO, engineered mitochondria that target inflammation and repair in acute organ injuries, showing efficacy in mouse models of myocardial, liver, and pancreatitis injuries.

Spp1 secreted by macrophages impairs osteogenic ability of Ctsk+Fmod+ periosteal cells in jaw bone

The paper identifies a Ctsk+Fmod+ periosteal cell subset in jaw bones that is impaired by Spp1 secreted by macrophages, highlighting a potential target for improving bone grafting.

eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

The paper identifies eIF3k as a regulator of ribosome content in cancer by showing its depletion increases global translation and stress resistance through repression of RPS15A synthesis.

Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes

This study investigates how EGFR dimers and higher-order oligomers form and interact in cell membranes using SPT and FRET, revealing the role of the tyrosine kinase domain in oligomerization.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma

The paper identifies NDC80 as a predictor of ccRCC progression and shows that NDC80-high tumors are sensitive to mitotic kinase inhibitors.

Injectable polymer-nanoparticle hydrogel for the sustained intravitreal delivery of bimatoprost

This paper develops an injectable polymer-nanoparticle hydrogel for sustained intravitreal delivery of bimatoprost, showing prolonged drug release and minimal inflammation in rabbits.

Beta human papillomavirus 8E6 promotes alternative end-joining

This study shows HPV8 E6 promotes alternative end-joining (Alt-EJ) by interacting with p300, leading to increased genomic instability and deletions with Alt-EJ signatures.

Response of sugarcane rhizosphere soil fungal communities on a temporal gradient to changes in critical growth periods

This study examines how sugarcane rhizosphere fungal communities change over time, identifying key fungal genera and environmental drivers affecting their structure and disease risk.

Aridity modulates biogeographic distribution and community assembly of cyanobacterial morphotypes in drylands

This study examines how aridity affects the distribution and community assembly of cyanobacterial morphotypes in drylands, finding that stochastic processes dominate but aridity influences the balance between determinism and stochasticity.

Suppression of tumor/host intrinsic CMTM6 drives anti-tumor cytotoxicity in a PD-L1 independent manner

This study shows that suppressing CMTM6 in tumors or hosts enhances anti-tumor immunity independently of PD-L1, suggesting CMTM6 as a target for gene therapy.

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

Selective Control of Parasitic Nematodes Using Bioactivated Nematicides

This study identifies selectivins, a family of imidazothiazole nematicides that are selectively activated in nematodes, offering effective and selective control of plant-parasitic nematodes.

Cell cycle stage classification using phase imaging with computational specificity

This paper introduces a method using phase imaging and neural networks to classify cell cycle stages without fluorescence, achieving high accuracy in G1, S, and G2/M classification.

Elevated transcriptional pausing of RNA polymerase II underlies acquired resistance to radiotherapy

This study identifies increased RNA polymerase II pausing as a mechanism of acquired radiotherapy resistance in cancer cells and suggests CDK7 inhibitors as a potential therapeutic strategy.

Cis-regulatory changes in locomotor genes are associated with the evolution of burrowing behavior

This study identifies cis-regulatory changes in locomotor genes associated with burrowing behavior evolution in Peromyscus mice by comparing gene expression and allele-specific expression in hybrids and post-burrowing mice.