MYC Functions as a Switch for Natural Killer Cell-Mediated Immune Surveillance of Lymphoid Malignancies
S. Swaminathan, L. Heftdal, D. Liefwalker, R. Dhanasekaran, A. Deutzmann, C. Horton, A. Mosley, M. Libersbach, H. Maecker, D. Felsher
This study shows that MYC in lymphomas inhibits NK cell maturation by suppressing STAT1/2 and IFN secretion, and restoring NK cells improves survival in lymphoma models.
bioRxiv · Dec 28, 2018Cancer Biology