Author

H. Maecker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 5 Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 7 Research Focus:differential expression· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3

Frequent Co-Authors

B. Pulendran· 2 shared J. G. Montoya· 2 shared Y. Rosenberg-Hasson· 2 shared A. Arrieta· 1 shared A. D. Augustine· 1 shared A. D. Shandling· 1 shared A. Deutzmann· 1 shared A. Hoch· 1 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

B. Pulendran

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants

J. P. Gygi, C. Maguire, R. K. Patel, P. Shinde, A. Konstorum, C. P. Shannon, L. Xu, A. Hoch, N. Jayavelu, IMPACC Network, E. K. Haddad, E. F. Reed, M. Kraft, G. A. McComsey, J. Metcalf, , Pete

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.

bioRxiv · Nov 3, 2023Immunology

Age-Associated Weaker Immunity to Coronaviruses is Characteristic of Children that Develop Multisystem Inflammatory Syndrome following SARS-CoV-2 Infection

D. Camerini, A. Arrieta, A. Randall, J. Gach, H. Maecker, J. Hoang, K. Imfeld, S. Osborne, C. Enriquez, C. Hung, J. Edgar, A. D. Shandling, V. Huynh, A. Teng, J. Pablo, , D. Nugent

The paper compares antibody and cytokine responses between MIS-C patients and convalescent COVID-19 children, finding weaker antibody responses and elevated proinflammatory cytokines in MIS-C.

bioRxiv · Aug 28, 2023 · PreprintImmunology

Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

J. Nideffer, M. Ty, M. Donato, J. Rek, R. Kajubi, X. Ji, H. Maecker, F. Nankya, K. Musinguzi, K. Press, B. Greenhouse, M. Kamya, M. E. Feeney, G. Dorsey, P. Utz, , P. Jagannathan

The paper shows that repeated Plasmodium infection leads to epigenetic changes in innate immune cells, which suppress inflammation and confer long-term disease tolerance in Ugandan children.

bioRxiv · Apr 19, 2023 · PreprintImmunology

Extending the dynamic range of biomarker quantification through molecular equalization

S. S. Newman, B. Wilson, D. Mamerow, B. Wollant, H. Nyein, Y. Rosenberg-Hasson, H. Maecker, M. Eisenstein, H. T. Soh

This paper introduces a method to extend the dynamic range of biomarker quantification by equalizing molecular signals, achieving seven orders of magnitude in a single undiluted sample.

bioRxiv · Feb 7, 2023Bioengineering

Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens.

M. S. Sumanth, Y. Liu, J. Wu, L. Fechter, K. Murugesan, H. Maecker, J. Gotlib, J. Zehnder, R. Paulmurugan, A. Krishnan

The paper identifies enkurin as a novel marker of myeloproliferative neoplasms (MPNs) through analysis of platelet, megakaryocyte, and whole blood specimens, showing inverse association with CDC20 and involvement of calcium homeostasis and ER stress.

bioRxiv · Jan 7, 2023Cancer Biology

Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics

M. L. Robinson, D. R. Glass, V. Duran, O. Rojas, A. M. Sanz, M. Consuegra, M. K. Sahoo, F. Hartmann, M. Bosse, R. M. G. Ramirez, N. Bueno, B. A. Pinsky, J. G. Montoya, H. Maecker, M. Cardenas, , S. Einav

The paper uses single-cell proteomics to analyze immune cell responses in severe dengue patients, identifying distinct immune dynamics compared to uncomplicated dengue.

bioRxiv · Sep 21, 2022Immunology

An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans

N. Sayed, T. Gao, R. j. Tibshirani, T. Hastie, L. Cui, T. Kuznetsova, Y. Rosenberg-Hasson, R. Ostan, D. Monti, B. Lehallier, S. Shen-Orr, H. Maecker, C. L. Dekker, T. Wyss-Coray, C. Franceschi, , D. Furman

The paper develops an inflammatory clock of aging (iAge) using blood immunome data from 1001 individuals, showing it correlates with multi-morbidity, immunosenescence, and cardiovascular aging.

bioRxiv · Nov 16, 2019 · PreprintImmunology

MYC Functions as a Switch for Natural Killer Cell-Mediated Immune Surveillance of Lymphoid Malignancies

S. Swaminathan, L. Heftdal, D. Liefwalker, R. Dhanasekaran, A. Deutzmann, C. Horton, A. Mosley, M. Libersbach, H. Maecker, D. Felsher

This study shows that MYC in lymphomas inhibits NK cell maturation by suppressing STAT1/2 and IFN secretion, and restoring NK cells improves survival in lymphoma models.

bioRxiv · Dec 28, 2018Cancer Biology