Structure of the connexin-43 gap junction channel in a putative closed state
C. Qi, S. Acosta-Gutierrez, P. Lavriha, A. Othman, D. Lopez-Pigozzi, E. Bayraktar, D. Schuster, P. Picotti, N. Zamboni, M. Bortolozzi, F. L. Gervasio, V. M. Korkhov
The paper determines the structure of a human Cx43 gap junction channel in a closed state using cryo-EM, revealing a previously unknown conformation stabilized by a small molecule.
bioRxiv · Mar 26, 2022Biochemistry