C. Qi

Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

The paper identifies two distinct binding sites for connexin channel inhibitors mefloquine and 2APB, showing they block channel function through different mechanisms.

Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity

The paper presents cryo-EM structures of human SIDT1 and SIDT2, revealing their dimeric architecture and demonstrating low-pH-dependent RNA binding and oligomerization.

Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels

The paper presents cryo-EM structures of wild-type and CMT1X mutant connexin 32 gap junction channels and hemichannels, revealing a gating helix defect in disease-associated mutants.

Experimental study of modified human tendon stem cells to promote graft ligamentation and tendon-bone healing after anterior cruciate ligament reconstruction

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

Cerebral malaria is regulated by host mediated changes in Plasmodium gene expression

The paper shows that Plasmodium ANKA parasites exhibit ECM-specific gene expression profiles that are activated only in susceptible hosts, indicating host influence on cerebral malaria outcomes.

HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography

The paper introduces HOPE-SIM, a cryo-CLEM system that improves targeting precision for cryo-ET by integrating 3D SIM and software, achieving 150 nm correlation accuracy.

Structural basis of organic cation transporter-3 inhibition

The paper determines the cryo-EM structure of OCT3 and analyzes genetic variants to understand its function and inhibition.

Structure of the connexin-43 gap junction channel in a putative closed state

The paper determines the structure of a human Cx43 gap junction channel in a closed state using cryo-EM, revealing a previously unknown conformation stabilized by a small molecule.

Structural basis of adenylyl cyclase 9 activation

The paper presents cryo-EM structures of AC9 in different states to reveal activator-induced conformational changes essential for its activation.

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among bloodstream isolates at a United States academic medical center

This study analyzes K. pneumoniae bloodstream isolates to determine the prevalence of multidrug-resistant and hypervirulent strains in a US hospital, finding high diversity and the presence of hypervirulent strains with potential for community spread.

Emerging Concern of Scientific Fraud: Deep Learning and Image Manipulation

This paper shows GANs can generate realistic western blot images that fool researchers, highlighting the need for better detection methods and image verification protocols.

Cryo-EM structure of the Hedgehog release protein Dispatched

This study presents the cryo-EM structure of Drosophila Dispatched, revealing its open conformation and unique Hh-binding mode, suggesting a receptor-chaperone role in Hedgehog release.

Structural basis of sterol recognition by human hedgehog receptor PTCH1

This study presents a cryo-EM structure of human PTCH1 bound to a modified hedgehog ligand, revealing sterol interactions and potential translocation pathways.