Author

A. Othman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1

Frequent Co-Authors

N. Zamboni· 3 shared A. Aloia· 1 shared A. Bileck· 1 shared A. Dzung· 1 shared A. Fadel· 1 shared A. Franco-Obregon· 1 shared A. Irmisch· 1 shared A. Leitner· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

N. Zamboni

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ROS induction as a strategy to target persister cancer cells with low metabolic activity in NRAS mutated melanoma

O. M. Eichhoff, C. I. Stoffel, J. Kaesler, L. Briker, P. Turko, G. Karsai, N. Zila, V. Paulitschke, P. F. Cheng, A. Leitner, A. Bileck, N. Zamboni, A. Irmisch, Z. Balazs, A. Tastanova, , M. Levesque

The paper identifies ROS induction as a strategy to target MEK-inhibitor resistant NRAS-mutated melanoma cells by exploiting their quiescent metabolic state and elevated baseline ROS levels.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

Structure of the connexin-43 gap junction channel in a putative closed state

C. Qi, S. Acosta-Gutierrez, P. Lavriha, A. Othman, D. Lopez-Pigozzi, E. Bayraktar, D. Schuster, P. Picotti, N. Zamboni, M. Bortolozzi, F. L. Gervasio, V. M. Korkhov

The paper determines the structure of a human Cx43 gap junction channel in a closed state using cryo-EM, revealing a previously unknown conformation stabilized by a small molecule.

bioRxiv · Mar 26, 2022Biochemistry

Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions

E. Yifrach, D. Holbrook-Smith, J. Burgi, A. Othman, M. Eisenstein, C. W. T. Van Roermund, W. Visser, A. Tirosh, C. Bibi, S. Galor, U. Weil, A. Fadel, Y. Peleg, H. Waterham, R. J. Wanders, , E. Zalckvar

The paper identifies new peroxisomal functions in yeast by expanding the organellar proteome and analyzing sub-organellar localization and metabolic roles.

bioRxiv · Dec 8, 2021Cell Biology

All-in-one comprehensive extraction of metabolites, proteins and ribonucleic acids for the rapid analysis of oil palm systems biology

S. Shahwan, A. Othman, N. Zain, N. L. Rozali, U. S. Ramli

The paper develops an all-in-one extraction protocol for metabolites, proteins, and RNA from oil palm root to support multi-omics analysis.

bioRxiv · Jul 1, 2020 · PreprintPlant Biology

Cell-Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities

F. Kurth, Y. K. Tai, D. Parate, M. van Oostrum, Y. R. F. Schmid, S. J. Toh, J. L. Y. Yap, B. Wollscheid, A. Othman, P. S. Dittrich, A. Franco-Obregon

This study shows that cell-derived vesicles from C2C12 myoblasts can restore mitochondrial function and proliferative capacity in recipient cells through TRPC1-mediated calcium entry.

bioRxiv · May 16, 2020Cell Biology