Gamblers: an Antibiotic-induced Evolvable Cell Subpopulation Differentiated by Reactive-oxygen-induced General Stress Response
J. P. Pribis, L. Garcia-Villada, Y. Zhai, O. Lewin-Epstein, A. Wang, J. Liu, J. Xia, Q. Mei, D. M. Fitzgerald, J. Bos, R. Austin, C. Herman, D. Bates, L. Hadany, P. J. Hastings, S. M. Rosenberg
The paper shows ciprofloxacin induces antibiotic-resistant mutations by creating a subpopulation of cells with activated sigma-S response, which allows error-prone repair and generates cross-resistant mutants.
bioRxiv · Dec 11, 2018Microbiology