Author

L. Garcia-Villada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Herman· 2 shared J. P. Pribis· 2 shared P. J. Hastings· 2 shared S. M. Rosenberg· 2 shared Y. Zhai· 2 shared A. Wang· 1 shared D. Bates· 1 shared D. M. Fitzgerald· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

C. Herman

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ppGpp and RNA-Polymerase Backtracking Guide Antibiotic-Induced Mutable Gambler Cells

Y. Zhai, P. J. Minnick, J. P. Pribis, L. Garcia-Villada, P. J. Hastings, C. Herman, S. M. Rosenberg

The paper identifies the stringent starvation response as a key driver of ciprofloxacin-induced mutagenesis through RNA polymerase and ppGpp-mediated DNA-damage signaling.

bioRxiv · Jul 6, 2022Microbiology

Gamblers: an Antibiotic-induced Evolvable Cell Subpopulation Differentiated by Reactive-oxygen-induced General Stress Response

J. P. Pribis, L. Garcia-Villada, Y. Zhai, O. Lewin-Epstein, A. Wang, J. Liu, J. Xia, Q. Mei, D. M. Fitzgerald, J. Bos, R. Austin, C. Herman, D. Bates, L. Hadany, P. J. Hastings, S. M. Rosenberg

The paper shows ciprofloxacin induces antibiotic-resistant mutations by creating a subpopulation of cells with activated sigma-S response, which allows error-prone repair and generates cross-resistant mutants.

bioRxiv · Dec 11, 2018Microbiology