Cancer BiologybioRxiv
Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition
J. J. Harding, M. A. Lowery, A. H. Shih…·A. M. Intlekofer
The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.
DOI 10.1158/2159-8290.cd-18-0877