B. Wu

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

Molecular basis of Ad5-nCoV Vaccine-Induced Immunogenicity

This study investigates the molecular basis of Ad5-nCoV vaccine-induced immunogenicity by analyzing the structure and properties of the spike antigens it induces.

hESCs-derived organoids achieve liver zonation by LSEC modulation

This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.

A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy

This paper identifies a novel HDAC inhibitor, STR-V-53, that effectively targets HCC and enhances immunotherapy responses in mouse models.

Border-zone cardiomyocytes and macrophages contribute to remodeling of the extracellular matrix to promote cardiomyocyte invasion during zebrafish cardiac regeneration

This study identifies border-zone cardiomyocytes and macrophages as key contributors to ECM remodeling that facilitates cardiomyocyte invasion during zebrafish cardiac regeneration.

Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neuromodulation Technology Development

This study explores photoelectric stimulation using ultrasmall carbon electrodes to modulate neural tissue, showing improved voltage generation and potential for precise chemical delivery.

Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification

This study identifies KIFC1 as a therapeutic vulnerability in lung cancers with centrosome amplification by showing its role in mitigating mitotic stress.

Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics

The paper uses spatial transcriptomics and proteomics to identify claudin-4 as a theranostic target in pancreatic cancer, showing its increased expression and suitability for molecular imaging.

Protein Engineering with Lightweight Graph Denoising Neural Networks

This study introduces a lightweight graph neural network for protein engineering that predicts fitness and guides the design of effective mutants with improved physicochemical properties.

Decoupling of the Onset of Anharmonicity between a Protein and Its Surface Water around 200 K

The paper investigates the onset of anharmonicity in a protein and its surface water around 200 K, finding they are decoupled, with the protein's transition being intrinsic and the water's being a resolution effect.

A conditional protein diffusion model generates artificial programmable endonuclease sequences with enhanced activity

This paper introduces CPDiffusion, a conditional protein diffusion model that generates artificial endonuclease sequences with enhanced activity without labeled data.

Evidence for gene transfer between mycoviruses and their host: Curvulaviridae as a case study

The paper investigates gene transfer between mycoviruses and their fungal hosts, focusing on the Curvulaviridae family, and finds evidence of host protein transfer to viral genomes.

Mn2+-Induced Structural Flexibility Enhances the Entire Catalytic Cycle and the Cleavage of Mismatches in Prokaryotic Argonaute Proteins

This study shows that Mn2+ enhances pAgo protein flexibility, improving catalytic efficiency and mismatch cleavage through structural changes.

Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

Implantable flexible multielectrode arrays for multi-site sensing of serotonin tonic levels

This paper develops implantable flexible microelectrode arrays for chronic in vivo measurement of tonic serotonin levels across multiple brain sites in mice.

Vascular endothelial growth factor A contributes to the increasing of mammalian respiratory epithelial permeability induced by Pasteurella multocida infection

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

Nanosecond pulsed electric field ablates rabbit VX2 liver tumors in a non-thermal manner versus radiofrequency ablation

This study compares nanosecond pulsed electric field (nsPEF) and radiofrequency ablation (RFA) in treating rabbit VX2 liver tumors, showing nsPEF induces apoptosis and non-thermal ablation.

Integration of microprism and microelectrode arrays enables simultaneous electrophysiology and two-photon imaging across all cortical layers

This paper introduces a device combining microelectrodes and microprisms for simultaneous electrophysiology and two-photon imaging across all cortical layers in mice.

The adipose-neural axis is critically involved in cardiac arrhythmias

This study shows that the adipose-neural axis contributes to cardiac arrhythmias through leptin-induced activation of sympathetic neurons and subsequent effects on cardiomyocytes.

Adipokine C1q/Tumor necrosis factor-related protein 3 (CTRP3) Attenuates Intestinal Inflammation via Histone Deacetylase Sirtuin 1 (SIRT1)/NF-κB Signaling

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

Differential regulation of GUV mechanics via actin network architectures

This study shows that actin network architecture and lumenal viscosity regulate GUV deformability, with crosslinkers and dendritic cortex reducing deformability compared to actin filaments alone.

Real-time feeding behavior monitoring by electrical penetration graph rapidly reveals host plant susceptibility to crapemyrtle bark scale (Hemiptera: Eriococcidae)

This paper develops an EPG-based method to rapidly assess plant susceptibility to crapemyrtle bark scale by analyzing real-time feeding behavior parameters.

Green Lacewing Chrysoperla rufilabris (Neuroptera: Chrysopidae) is a potential biological agent for controlling crapemyrtle bark scale (Hemiptera: Eriococcidae)

This study confirms that larval green lacewing Chrysoperla rufilabris preys on crapemyrtle bark scale at different life stages and shows its potential as a biological control agent.

Genetic Diversity of Candidatus Liberibacter asiaticus Based on Four Hypervariable Genomic Regions in China

This study analyzes genetic diversity of Candidatus Liberibacter asiaticus in China using hypervariable genomic regions to understand strain differences and inform HLB control strategies.

Phototherapy with physically and molecularly produced light for Alzheimer's disease

This study shows that combining a photolabile Aβ ligand with LED or molecular light can reduce Aβ accumulation in mice, suggesting a new phototherapy approach for Alzheimer's disease.

A chromosome-level phased Citrus sinensis genome facilitates understanding Huanglongbing tolerance mechanisms at the allelic level in an irradiation induced mutant

The paper presents a chromosome-level phased genome of Valencia sweet orange, enabling allelic-level analysis of Huanglongbing tolerance in mutants.

Scale Bar of Aging Trajectories for Screening Personal Rejuvenation Treatments

This study develops an aging clock based on blood transcriptome data to assess aging rates and evaluate rejuvenation treatments like NMN and Metformin.

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

This study shows that ERK2 phosphorylates GLI1 at three sites, weakening its binding to SUFU and enhancing GLI1 activation, contributing to Hedgehog-MAPK pathway crosstalk in cancer.

Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death