BiochemistrybioRxiv
Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign
T. Aggarwal, W. A. Hansen, J. Hong…·E. C. Izgu
This paper redesigns an archaeal DNA polymerase to catalyze non-natural phosphoramidate linkages using structure-guided mutations.
DOI 10.1021/acschembio.2c00373