Reduced purine biosynthesis in humans after their divergence from Neandertals
V. Stepanova, K. E. Moczulska, G. N. Vacano, X.-c. Ju, S. Riesenberg, D. Macak, T. Maricic, L. Dombrowski, M. Schörnig, K. Anastassiadis, O. Baker, R. Naumann, E. E. Khrameeva, A. Vanyushkina, E. Stekolschikova, , S. Pääbo
The paper compares metabolomes across humans, chimpanzees, and macaques to identify reduced purine biosynthesis in humans, linked to an amino acid substitution in adenylosuccinate lyase.
bioRxiv · May 11, 2020Evolutionary Biology