Evolutionary BiologybioRxiv
Reduced purine biosynthesis in humans after their divergence from Neandertals
V. Stepanova, K. E. Moczulska, G. N. Vacano…·S. Pääbo
The paper compares metabolomes across humans, chimpanzees, and macaques to identify reduced purine biosynthesis in humans, linked to an amino acid substitution in adenylosuccinate lyase.
DOI 10.7554/elife.58741