Author

V. Stepanova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1

Frequent Co-Authors

D. B. Cines· 2 shared M. Poncz· 2 shared S. V. Zaitsev· 2 shared A. Saiyed· 1 shared A. Vanyushkina· 1 shared B. J. Buckley· 1 shared B. Piper· 1 shared D. Goncharov· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

D. B. Cines

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Author profile →

3 papers

Recent·Most cited

Packaging of supplemented urokinase into naked alpha-granules of in vitro-grown megakaryocytes for targeted therapeutic delivery

M. Poncz, S. V. Zaitsev, H. Ahn, M. A. Kowalska, K. Bdeir, R. M. Camire, D. B. Cines, V. Stepanova

The paper demonstrates that in vitro-grown megakaryocytes can store exogenous uPA in alpha-granules, which can be used to generate anti-thrombotic human platelets that lyse nascent thrombi in a mouse model.

bioRxiv · Dec 5, 2023 · PreprintCell Biology

PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hy-pertension

T. V. Kudryashova, S. V. Zaitsev, L. Jiang, B. J. Buckley, J. P. McGuckin, D. Goncharov, I. Zhyvylo, D. Lin, G. Newcomb, B. Piper, S. Bogamuwa, A. Saiyed, L. Teos, M. Ranson, P. Wolters, , V. Stepanova

This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.

bioRxiv · Sep 21, 2023Cell Biology

Reduced purine biosynthesis in humans after their divergence from Neandertals

V. Stepanova, K. E. Moczulska, G. N. Vacano, X.-c. Ju, S. Riesenberg, D. Macak, T. Maricic, L. Dombrowski, M. Schörnig, K. Anastassiadis, O. Baker, R. Naumann, E. E. Khrameeva, A. Vanyushkina, E. Stekolschikova, , S. Pääbo

The paper compares metabolomes across humans, chimpanzees, and macaques to identify reduced purine biosynthesis in humans, linked to an amino acid substitution in adenylosuccinate lyase.

bioRxiv · May 11, 2020Evolutionary Biology